|
" بررسی اثربخشی دو روش تجویز سیستمیک ایبوپروفن و تجویز موضعی ژل لیدوکائین در کاهش درد حین جرمگیری و تسطیح ریشه در بیماران با پریودنتیت خفیف تا متوسط "
/آرمن الکساندریان
؛ محمد شاه‌ابویی، جابر یقینی
؛ ابوالفضل اصلانی
| center
|
:
|
Isfahan University of Medical Sciences
|
| Document Type
|
:
|
Latin Dissertation
|
| Language of Document
|
:
|
English
|
| Record Number
|
:
|
105749
|
| Doc. No
|
:
|
T16381
|
| Call number
|
:
|
QW525.5,S447e,2016
|
| Main Entry
|
:
|
Sedaghat, Nahid
|
| Title & Author
|
:
|
Evaluation the frequency of the peripheral blood CD4+FoxP3+ regulatory T cells expressing the lymphocyte activation gene 3 (LAG-3; or CD223) in the Multiple sclerosis patients before and after treatment with Fingolimod\ Nahid Sedaghat
|
| College
|
:
|
Schools, Medical
|
| Date
|
:
|
, 2016
|
| Degree
|
:
|
Immunology, Medical, MS
|
| Page No
|
:
|
63p.:ill, diag, tab
|
| Note
|
:
|
This is a research dissertation with project ID: 392566
|
| Abstract
|
:
|
IntroductionMultiple sclerosis (MS) is an autoimmune disease in which seems there is a defect in regulatory cells. It is thought that regulatory T cells expressing lymphocyte Activation Gene3 (LAG-3), and encounter effectively with the effector lymphocytes and endow a suppressor activity to these cells during the regulatory T cell homeostasis. This thesis aimed to evaluate the frequency of the peripheral blood CD4+FoxP3+LAG-3+ T cells before and after 1 month of Fingolimod treatment. Materials and MethodsBlood samples were obtained from 20 patients with Relapsing Remitting Multiple sclerosis (RRMS) before and after 1 months of Fingolimod treatment, and from 12 age-matched healthy control individuals. The frequency of regulatory T cells expressing the LAG-3 was determined by the flow cytometry method.ResultsThe frequency of the peripheral blood CD4+FoxP3+ regulatory T cells in the MS patients compared to baseline increased (P= 0.002). In addition, Fingolimod increased significantly the peripheral blood regulatory T cells expressing the LAG-3, (P= 0.005).
|
| Descriptor
|
:
|
Lymphocyte Activation
|
|
|
:
|
Multiple Sclerosis, Relapsing-Remitting
|
|
|
:
|
Fingolimod Hydrochloride
|
|
|
:
|
Immunosuppressive Agents
|
|
|
:
|
Gene Expression
|
| Added Entry
|
:
|
Zarkesh Esfahani , Hamid, Thesis advisor
|
|
|
:
|
Alsahebfosoul, Fereshteh, Thesis advisor
|
|
|
:
|
Etemadifar , Masood, Consulting advisor
|
| Translated Title Supplied by Cataloguer
|
:
|
بررسی فراوانی سلول های تی تنظیمی در خون محیطی بیماران مبتلا به مالتیپل اسکلروزیس قبل و بعد از درمان با داروی فینگولیمود
|
| |