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" Concomitant adminstration of vitamin E does not change the side effects of acitretin: A randomized controlled study "
; Ali Asilian
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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102521
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| Doc. No
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T6849
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| Call number
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WR,205,O55c,2000
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| Main Entry
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Omidghaemi, Mohamadreza
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| Title & Author
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Concomitant adminstration of vitamin E does not change the side effects of acitretin: A randomized controlled study
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| College
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Schools, Medical
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| Date
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, 2000
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| Degree
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Dermatology, Speciality
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| Page No
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12, 4 P.: tab
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| Note
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This thesis is also a research project with project ID 78308
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| Abstract
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Background: Acitretin treatment is frequently associated reversible, dose- related side effecs. Recent studies ciaimed that combining vitamin E with high- dose isotretionoin ameliorated isotretinion induced effects. Objective: The purpose of this clinical trial study was to determine the effect of a fixed or adjusted dose of vitami E on the side effecs of acitretin for treatment of certain types of psoriasis and P.R.P, E. Verruciformis, lamellar ichthyosis and darier's disease. Methods: Fifty five subjects were randomly assigned to one of the two treatment programs with acitretin (0.7-1 mg/kg/d) together with either vitamin- E (13 IU/Kg/day) or alone for 3 months. The incidence of side effects of acitrecin in two groups were assessed. Results: The study was completed in thity nine patients. Vitamin E (13 IU/Kg/day) did not decreased the incidence of side effects associated with acitretin (0.7-1 mg/kg/day). Conclusion: Vitamin E did not significantly ameliorate retinoid side effects when combined with 0.7-1 mg/kg of acitretin in treatment of psoriasis, P.R.P (Pityriasis rubra pilaris), E.V (Epidemodysplasia verruciformis), Lamellar Ichthyosis and darier's disease.
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| Subject
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Psoriasis- Drug theraphy
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| Descriptor
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Acitretin
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Psoriasis- Drug Theraphy
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Vitamin E
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Retinoids
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| Added Entry
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Asilian, Ali
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