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" Phytochemical Study of aremisia persica boiss And evaluation of it,s antiplasmodial Activity "
; Asghari, CholamReza; Shams Ardekani, Mohammad Reza; Jaroszewski, Jerzy W.
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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102536
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| Doc. No
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T9036
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| Call number
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QV,766,S125p,2004
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| Main Entry
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Sadeghpour, Omid
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| Title & Author
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Phytochemical Study of aremisia persica boiss And evaluation of it,s antiplasmodial Activity
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| College
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Schools, Pharmacy
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| Date
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, 2004
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| Degree
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Pharmacognosy, Ph.D
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| Page No
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151 p.: illus, fig, tab
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| Note
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This thesis is a also a research project with project ID 80144
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| Abstract
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Title: Phytochemical Study of Artemisia persica Boiss. and Evaluation of its Antiplasmodial ActivityOmid Sadeghpour, Gholamreza Asghari, Mohammad Reza Shams Ardekani, Jerzy W. Jaroszewski andIntroductionThe genus Artemisia is one of the largest and most widely distributed of the nearly 100 genera in the tribe Anthemideae of the Asteraceae (Compositae).Considering to different compounds exist in Artemisia spp. they have a wide variety of biological activity.The outstanding antimalarial compound, artemisinin, isolated from Artemisia annua.The aim of this study was phytochemical investigation of the plant belongs to the genus Artemisia "Artemisia persica" in order to identify bioactive compounds which may have antiplasmodial effect.MethodsThe plant was collected from Isfahan province / IRAN, and undergoes to chemical isolation of compounds by VLC, CC and HPLC.The essential oil of A. persica was obtained by hydrodistillation and analysed by GC/MS. ResultsThe yield of essential oil was 0.40 . Davanone is the major constituent of the essential oil.Phytochemical investigation of the extract led to isolation of Friedelin, Ascaridol, Scopoletin, Scopolin, a flavonoid and two other unknown compounds.Methanolic extract of Artemisia persica showed a moderate effect against the Plasmodium parasite compared to Chloroquine.DiscussionDavanone was the major constituent of Artemisia persica while the other studies indicated that the major constituent of volatile oil is 1,8- Cineol.The results showed that although the isolated compounds like Friedelin, Ascaridol, Scopoletin and etc from Artemisia persica may have different biological activity but not high antiplasmodial.However comparing with artemisinin the compounds Ascaridol and Friedelin (specially its derivative, B-Amyrin) showed week antiplasmodial effect. In conclusion it is improbable to find major compounds with high antimalarial effect in Artemisia persica..
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| Subject
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Plants, Medicinal
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| Descriptor
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Plants, Medicinal
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Artemisia Persica Boiss
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Plant Extracts
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Plasmodium
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Malaria
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Parasites
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Antimalarials
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Drug Evaluation
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Chromatography, High Pressure Liquid
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گیاهان شفابخش
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درمنه
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عصارههای گیاهی
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پلاسمودیوم
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مالاریا
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انگلها
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ضد مالاریاها
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ارزیابی دارو
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کروماتوگرافی مایع با کارآیی بالا
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| Translated Title Supplied by Cataloguer
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بررسی فیتوشیمیایی گیاه Artemisia Persica Boiss و ارزیابی فعالیت ضد پلاسمودیایی آن
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