| |
| center
|
:
|
Isfahan University of Medical Sciences
|
| Document Type
|
:
|
Latin Dissertation
|
| Language of Document
|
:
|
English
|
| Record Number
|
:
|
102538
|
| Doc. No
|
:
|
T9038
|
| Call number
|
:
|
QV,785,T128p,2003
|
| Main Entry
|
:
|
Tahvilian, Reza
|
| Title & Author
|
:
|
Preparation of a buccal delivery system of cisapride, evaluation of buccal absorption And Comparison its bioavailability with standards oral dosge from
|
| College
|
:
|
Schools, Pharmacy
|
| Date
|
:
|
, 2003
|
| Degree
|
:
|
Pharmaceutical, Ph.D
|
| Page No
|
:
|
189 p.: illus, fig, tab
|
| Note
|
:
|
This thesis is also a research with project ID 79318
|
| Abstract
|
:
|
The mucosal lining of the oral cavity is readily accessible, robust, and heals rapidly after local stress or damage. Oral mucosal drug delivery systems can be localized easily and are well accepted by patients and can serve as a site forsystemic drug delivery In this study, cisapride was applied to prepare a buccal tablet. The bioadhesion of buccal tablets were evaluated using Texture Analyzer (in- vitro). The availability of buccal tablet of cisapride was compared with peroral tablet in human volunteers. In addition, their bioadhesion was evaluatet in these subjects. The dissolution profile of drug release from buccal tablets was studied in a medium like saliva solution. The bioequivalency of peroral cisapride tablet made by Sobhan Inc. with comparison to Propulsid made by Janssen Inc. Was also studied in-vitro and in- vitro. Its plasma concentration was determind by designing an accurate and sensitive HPLC method using UV detectors. A mixture of three hydrophilic polymers, Na CMC, HPMC and Carbopol P 934, has been used as an optimum matrix for releasing cisapride with good bioadhesion human subjects. This indicated on improved bioavailaability of the buccal tablet compared to Propulsid..
|
| Descriptor
|
:
|
1. Drug Delivery System.- Descriptors: Drug Evaluations
|
|
|
:
|
Tabletes
|
|
|
:
|
Drug Delivery Systems
|
|
|
:
|
Drug Administration Schedule
|
|
|
:
|
Administration, Oral
|
|
|
:
|
Drug Resistance
|
|
|
:
|
Biological Availability
|
|
|
:
|
Cisapride
|
| Added Entry
|
:
|
Flamarzian, M, Supervisor
|
|
|
:
|
Emami, J, Supervisor
|
|
|
:
|
Varshosaz, J, Supervisor
|
| | | | | |
| | |  |
http://elib.mui.ac.ir/site/catalogue/102538
| | | |
| | | |
|