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center : Isfahan University of Medical Sciences
Document Type : Latin Dissertation
Language of Document : English
Record Number : 102539
Doc. No : T9012
Call number : ‭WL,385,717e,2003‬
Main Entry : Molaei, Sanaz
Title & Author : Epilepsy in Boys with duchenne mmuscular Dystrophy
College : Schools, Medical
Date : , 2003
Degree : Medicine, MD
Page No : 12 p.
Abstract : Introduction : Regarding the unexpected frequency of epilepsy in patients with DuchenneMuscular Dystrophy ( DMD ) , this study was conducted to assess the impression of"Duchenne - related epilepsy".Methods : After definite diagnosis of DMD in 57 children attended to the neurology clinics , aquestionnaire including demographic variables and data related to symptom presentationswas completed . if history of epilepsy was present , complementary information on thebackground of epilepsy ( based on history taking and paraclinical data ) was obtained .Results : Among 54 patients with DMD , seven cases ( 12.3 percent ) had the history ofepilepsy versus 0.4 - 0.5 percent in general population ( p<0.001 )). Known causes of epilepsywere ruled out in these patients. From 7 patients with epilepsy , 6 caese had mild mentelretardation and one of them had normal mental status .Discussion : Our data suggests that epilepsy may be a rare associated feature of DMD ,maybe secondary to abscence of dystrophin in the central nervous system ( CNS ) because ofits role in the inhibitory synapses of cortex & hypocampus..
Descriptor : Convulsions
: Muscular Dystrophines
: Muscular Dystrophy, Duchenne
: Central Nervous System
: Synapses
: Hippocampus
: Mental Retardation
: Medical History Taking
: Anticonvulsants
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Epilepsy in Boys with duchenne mmuscular Dystrophy
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