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Isfahan University of Medical Sciences
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Document Type
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Latin Dissertation
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Language of Document
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English
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Record Number
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102539
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Doc. No
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T9012
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Call number
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WL,385,717e,2003
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Main Entry
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Molaei, Sanaz
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Title & Author
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Epilepsy in Boys with duchenne mmuscular Dystrophy
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College
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Schools, Medical
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Date
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, 2003
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Degree
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Medicine, MD
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Page No
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12 p.
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Abstract
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Introduction : Regarding the unexpected frequency of epilepsy in patients with DuchenneMuscular Dystrophy ( DMD ) , this study was conducted to assess the impression of"Duchenne - related epilepsy".Methods : After definite diagnosis of DMD in 57 children attended to the neurology clinics , aquestionnaire including demographic variables and data related to symptom presentationswas completed . if history of epilepsy was present , complementary information on thebackground of epilepsy ( based on history taking and paraclinical data ) was obtained .Results : Among 54 patients with DMD , seven cases ( 12.3 percent ) had the history ofepilepsy versus 0.4 - 0.5 percent in general population ( p<0.001 )). Known causes of epilepsywere ruled out in these patients. From 7 patients with epilepsy , 6 caese had mild mentelretardation and one of them had normal mental status .Discussion : Our data suggests that epilepsy may be a rare associated feature of DMD ,maybe secondary to abscence of dystrophin in the central nervous system ( CNS ) because ofits role in the inhibitory synapses of cortex & hypocampus..
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Descriptor
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Convulsions
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Muscular Dystrophines
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Muscular Dystrophy, Duchenne
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Central Nervous System
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Synapses
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Hippocampus
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Mental Retardation
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Medical History Taking
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Anticonvulsants
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http://elib.mui.ac.ir/site/catalogue/102539
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