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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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102576
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| Doc. No
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T9563
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| Call number
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QV,785,D179l,2005
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| Main Entry
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Daneshamouz, Saeid
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| Title & Author
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Liposome- mediated Targeting of Finasteride to the Hair Follicles
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| College
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Schools, Pharmacy
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| Date
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, 2005
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| Degree
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Pharmaceutics, Ph.D
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| Page No
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m, 188, xviii p.: Diag., Tab.
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| Note
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This thesis is also as a project with project ID 79340
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| Note
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Orginal Studies
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| Abstract
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Introduction: Targeted delivery of finasteride, indicated orally in the treatment of alopecia and some other pilosebaceous disorders, to the hair follicles can increase the concentration of the drug at pilosebaceous units (PU) while reducing its systemic side effects. Methods: Finasteride-entrapped multilamellar liposomes/niosomes (MLVs) were prepared by the film formation and reverse evaporation methods. The MLVs were characterized with regard to the size, drug entrapment efficiency, and release behavior in various media and drugs permeability through different membranes. In vivo deposition of 3H-finasteride into PU and other compartments of the hamster ear was determined following topical application of finasteride-MLVs and a hydroalcoholic finasteride solution (HA) by scraping method. The decrease in the area of the ear and flank sebaceous glands after twice a day/4 weeks topical application was quantitatively determined by planimetry of histological sections of skin. Results: Finasteride permeation through hamster flank skin was faster from finasteride-HA than from finasteride-vesicles (0.13 vs. 0.025-0.058 [tg/cm2.h, respectively)), (P<0.05). The T50 release from liquid-state liposomes/niosomes intoartificial sebum at 37 ░C ranged from 2.5 to 7.5 h. Un-extruded charged MLVs comprising liquid-state amphiphiles of Brij97, dimyristoyl phosphatidylcholine (DMPC), Brij97:Brij76 (1:1 mole ratio) deposited 2.05-2.5 of the applied dose to the PU. This was significantly higher than 0.35-0.92 , which was deposited by extruded vesicles (100, 400 nm) of the same liquid-state amphiphiles, gel-state vesicles, or finasteride-HA. Selected finasteride-MLVs, HA of finasteride and a hydroalcoholic progesterone solution (positive control) significantly decreased the size of PU of ear and flank organ located under application site (36-48 , p<0.01), while HA of finasteride exhibited a systemic effect as determined by measuring the PU size in untreated side of the flank (p<0.05). Conclusion: Both in vivo deposition and in vivo bioassay studies demonstrated the potential of charged liquid-state MLVs for effective delivery of finasteride to the PU..
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| Descriptor
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1. Drug Delivery Systems.- Descriptors: Drug Delivery Systems
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Finasteride
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Hair Follicle
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Liposomes
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Dosage Forms
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| Added Entry
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Tabbakhian, Majid, Supervisour
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Tavakoli, Naser, Supervisour
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Jaffari, Mahmoud Reza, Supervisour
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| Translated Title Supplied by Cataloguer
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دارورسانی هدفمند فیناستراید به فولیکول مو توسط سیستمهای لیپوزومی
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http://elib.mui.ac.ir/site/catalogue/102576
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