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" The effect of utilizing levothyroxine with and without folic acid on serum homocysteine level in hypothyroid patients "
/علی حاجیغلامی
; Hasan Rezvanian
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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102583
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| Doc. No
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T9656
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| Call number
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WK,250,H154t,2005
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| Main Entry
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HajiGholami, Ali
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| Title & Author
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The effect of utilizing levothyroxine with and without folic acid on serum homocysteine level in hypothyroid patients/علی حاجیغلامی
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| College
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Schools, Medical
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| Date
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, 2005
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| Degree
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Internal medicine, Speciality
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| Page No
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54 P.:ill, Tab, fig
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This is a research dissertation with project Id 82403
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| Note
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Orginal Works
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| Abstract
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Objectives: Elevated level of serum homocysteine has been reported in hypothyroid patients. Considering the fundamental role of folate in the metabolic cycle of homocysteine, this study was performed to compare the level of homocysteine in patients with hypothyroidism following treatment either with levothyroxine alone or by levothyroxine in combination with folic acid.Methods: In this double-blind clinical trial study, 60 hypothyroid patients were randomly divided into two 30-people groups. Both groups were treated with 50-100 -إg of levothyroxine, and the case group was given an additional 1 mg acid folic tablet, whereas the controls were given placebo. The level of fasting homocysteine, folic acid, and Vitamin B12 was measured in all the subjects at the beginning of the study and after TSH levels were normalized. orResults: The level of homocysteine in the case group was decreased from 15.77▒6.33 limol/1 to 10.8▒3.54 jamo1/1 (P=0.000), and was also decreased in the control group from 15.69▒6.4 pno1/1 to 13.9▒6 umo1/1 (P=0.03). The difference in the mean serum homocysteine level between 2 groups was statistically significant (P=0.0165).K Conclusions: Although the level of homocysteine was decreased in both groups, the amount of decrease was greater in the group that was receiving levothyroxine and folic acid. Considering the fact that for every I umo1/1 increase in homocysteine level a 6-7 greater chance of cardiovascular diseases exits, our research indicated that using folic acid in conjunction with levothyroxine can lower the potential side affects of this substance, which can be exerted even in short period of time..
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| Descriptor
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1.Hypothyroidism.- Descriptors: Hypothyroidism
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Levothyroxine
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Homocysteine
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Folic Acid deficiency
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Hypoproteinemia
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Cardiovascular Diseases
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Risk Factors
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| Added Entry
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Rezvanian, Hasan, Supervisor
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| Translated Title Supplied by Cataloguer
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بررسی تاثیر استفاده از لووتیروکسین و اسید فولیک در مقایسه با لووتیروکسین بر سطح هموسیستئین مبتلایان به هیپوتیروئیدیسم
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