خط مشی دسترسی
پرسش و پاسخ
Isfahan University of Medical Sciences
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Title & Author
Valproate- Risperidone Versus Valproate- Lithium Combination In Acute Mania/آلاله فاطمی
8 P.:diag, Tab
This thesis is also presented as a paper in Journal of Research in Medical Sciences 2005; 10(5) with cooperation Nasrollahe Bashardost, Afshin Daroghe, Mehrdad Salehi, Ghorbanali Asadollahi, ...
Background: We evaluated the efficacy of valproate plus risperidone versus valproate plus lithium combination in the treatment of acute mania.Methods: In 2-week, randomized, double-blind, parallel group study, 46 acute manic patients according to DSM-IV criteria were randomly assigned to receive combination of valproate 20 mg/ kg/day plus risperidone 2-4 mg/day (n=23) or lithium600-1200 mg/day (n=23). The assessment of efficacy measures were according to Young Mania Rating Scale (YMRS) and Clinical Global Impressions-Severity (CGI-S) and Improvement (CGI-I) scale. Other effectiveness measures included YMRS response (YMRS reduction 50 ) and YMRS remission (YMRS total scores <12)).k.Results: In each group, 16 of 23 patients (70 ) completed the study. YMRS response, CGI-Improvement, and reduction in the total scores of YMRS and CGI-S observed in both groups, significantly greater for valproate-risperidone than valproate-lithium combination group (P=0.006, P=0.015, P=0.004, and P=0.007, respectively).YMRS remission were shown in both groups without statistical significance (P=0.073). The total scores of YMRS at 4th, 8th, and 14th days of trial were lower in valproate-risperidone than valproate-lithium combination group (P=0.017, P=0.005, and P=0.004, respectively). The rate of adverse events and means, weight gain in both groups were not statistically different.P\Conciusion: In acute manic patients, both combinations of valproate with lithium or with risperidone had efficacy in acutely rilanic patients, but valproate-risperidone combination was more effective. Both treatments were safe and well tolerated. Considering the small sample size and limited period of observation, further studies need to be conducted to find out the bestcombination in the treatment of acute mania. Bipolar mood disorder(BMD-1) is a common mental illness. The risks of morbidity and mortality of its intense manic episodes often requires hospitalization and rapid controlling of impulsivity, aggression, irritability, agitation, and psychotic symptoms. The primary goals of treatment for mania are to accelerate behavioral restoration as quickly as possible to decrease dangerousness to self and others, and limit the costs of manic episodes 1.For swift control of acute mania, adjunctive agents including combinations of two moodstabilizers or of a mood stabilizer with an antipsychotic agent are broadly used2-4 .Typical antipsychotics are commonly used in combination with mood stabilizers for acute mania. Beside the effectiveness of typical antipsychotics, they lead to side effects such as induction of depressive symptoms and tardive dyskinesia 5. Atypical antipsychotics have more favorable side effect profiles 6, 7 and as a class, recent evidences have shown their efficacy in mania combination therapy..
1. Bipolar Disorder- drug therapy.- Valproic Acid
Manic Disorders- drug therapy
Bipolar Disorders- drug effects
Drug Administration Schedule
Barekatain, Majid, Superviser
Translated Title Supplied by Cataloguer
مقایسه اثر درمانی والپروات سدیم و ریسپریدون با والپروان سدیم و لیتیم در مانیای حاد
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Valproate- Risperidone Versus Valproate- Lithium Combinat...
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