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" Comparison Between the Efficacy of Photodynamic Therapy and Topical Paromomycine in the Treatment of Old World Cutaneous Leishmaniasis - A Placebo- controlled, Randomized Clinical Trial "
/مجید دوامی
; Ali Asilian
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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102607
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| Doc. No
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T9981
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| Call number
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WR,350,D245c,2006
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| Main Entry
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Davami, Majid
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| Title & Author
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Comparison Between the Efficacy of Photodynamic Therapy and Topical Paromomycine in the Treatment of Old World Cutaneous Leishmaniasis - A Placebo- controlled, Randomized Clinical Trial/مجید دوامی
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| College
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Schools, Medical
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| Date
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, 2006
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| Degree
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Dermatology, Speciality
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13 p., ii: tab
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| Note
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Original Works
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| Abstract
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Background. The optimal treatment for cutaneous leishmaniasis (CL) is not known. Topical paromomycin is one of the many drugs that have been suggested for the treatment of CL caused by Leishmania major. Recently, topical photodynamic therapy (PDT) has been reported to be effective in the treatment of CL. Aims: To compare the parasitological and clinical efficacy of PDT versus topical paromomycin in patients with old world CL caused by L. major in Iran. Methods: In this trial, sixty patients with the clinical and parasitological diagnosis of CL were recruited and were randomly divided into three twenty subject treatment groups. Group 1 was treated with weekly topical PDT and groups 2 and 3 received twice daily topical paromomycin and placebo, respectively. The duration of treatment was four weeks for all groups. These groups were followed for 2 months after the end of treatment. Results: 57 patients with 95 lesions completed the study. At the end of the study, complete improvement was seen in 29 of 31(93.5 ), 14of 34(41.2 ) and 4of 30(13.3 ) of the lesions in group 1, 2 and 3 respectively (P< 0.001)). At the same time point, 100 , 64.7 and 20 of the lesions had parasitological cure in group 1, 2 and 3, respectively (P< 0.001).Conclusion: Topical PDT can be used safely as a rapid and highly effective alternative choice for treatment of old world CL in the selected patients..
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| Descriptor
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1. Leishmaniasis, Cutaneous.- Descriptors: Leishmaniasis, Cutaneous
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Leishmaniasis, Cutaneous- therapy
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Photochemotherapy
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Paromomycin
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Clinical Trial
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| Added Entry
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Asilian, Ali, Supervisor
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