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" Lidocaine versus second dosse of thiopentone for attenuating the cardiovascular response to endotracheal intubation Al-ZAhra hospital, Isfahan- Spring 2006. Mohamad Yaribakht "
/محمد یاریبخت
; A. Honarmand, M. Safavi Homami
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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102617
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| Doc. No
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T10272
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| Call number
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QV,115,Y28l,2006
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| Main Entry
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Yaribakht, Mohammad
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| Title & Author
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Lidocaine versus second dosse of thiopentone for attenuating the cardiovascular response to endotracheal intubation Al-ZAhra hospital, Isfahan- Spring 2006. Mohamad Yaribakht/محمد یاریبخت
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| College
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Schools, Medical
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| Date
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, 2006
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| Degree
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Medicine, MD
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78 p.: diag, tab
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| Note
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Orginal Works
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| Abstract
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Intubation with direct laryngoscopy, even in the most experienced hands and under ideal conditions, is associated with several potential stresses. Aim of this study was to determine the effects of premedication with thiopental (second dose) or lidocaine on heart rate, blood pressure, and oxygen saturation during endotracheal intubation.Methods: A randomized, placebo controlled, double-blinded study of 120 patients requiring elective endotracheal intubation. The patients were randomly allocated to receive either41 or 2 mg.kg-1 of thiopental, lidocaine 1.5 mg.kg-1 (study groups) or physiological saline (control group) one minute before the start of the procedure. The electrocardiogram, arterial pressure wave, and transcutaneous oxygen saturation were recorded continuously 5 minutes before, during, and 10 minutes after intubation. Minute by minute measurements of heart rate, rnPqn blood pressure and oxygen saturation were computed. The differences for all of these between the baseline measurements and those made during and after intubation were determined. Results: we observed that significant differences in homodynamic values started 1 min after intubation and lasted approximately 5 minutes. Placebo group had the highest levels of SBP, DBP, MAP, HR and RPP. Lidocaine group had the lowest levels of SBP, DBP, MAP, and RPP. Thiopenton 2 group had, the lowest levels of HR until 3 minutes after intubation, but 5 min after intithastion lidocaine group had lowest level of HR. Comparing data achieved before and after laryngoscopy showed that significant changes in hemodynamic values during 1, 3, and 5 minutes after intubation were higher in placebo group. Mean values of changes in SBP, HR and RPP until 3 min after intubation were significantly lower in thiopenton 2 group, but, mean values of changes in MAP and DBP were lower in. lidocaine group. Discussion: The data obtained in this trial supports the hypothesis that patients premedicated with lidocaine or second dose of thiopenton (2mg.kg-1) maintained homodynamic indexes closer to baseline values than patients who were premedicated either with second dose thiopenton (1mg.kg-1) or placebo..
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| Descriptor
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1. Lidocaine.- Descriptors: Laryngoscopy
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Heart Rate
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Blood Pressure Determination
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Lidocaine
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Thiopental
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Intubation, Intratracheal
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Premedication
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Saline Solution, Hypertonic
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| Added Entry
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Honarmand, A, .Supervisor
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Safavi Homami, M, .Supervisor
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