| |
| center
|
:
|
Isfahan University of Medical Sciences
|
| Document Type
|
:
|
Latin Dissertation
|
| Language of Document
|
:
|
English
|
| Record Number
|
:
|
102630
|
| Doc. No
|
:
|
T10405
|
| Call number
|
:
|
WR,143,D224n,2006
|
| Main Entry
|
:
|
Darougheh, Afshin
|
| Title & Author
|
:
|
New Combination Of Triamcinolone, 5-Fluorouracil, and Pulsed- Day Laser For the Treatment Of Keloid and Hypertrophic Scars. Afshin Darougheh/افشین داروغه
|
| College
|
:
|
Schools, Medical
|
| Date
|
:
|
, 2006
|
| Degree
|
:
|
Dermatology, Speciality
|
| Page No
|
:
|
no paging: ill, diag, tab
|
| Note
|
:
|
Orginal Works
|
| Abstract
|
:
|
BACKGROUND Keloids and hypertrophic scars are benign growths of dermal collagen that usually cause major physical, psychological, and cosmetic problems.METHODS In this 12-week single-blinded clinical trial, 69 patients were randomly assigned into three study groups. In Group 1, intralesional triamcinolone acetonide (TAC, 10 mg/mL) was injected at weekly intervals for a total of 8 weeks. In Group 2 ITAC + 5- fluorouracil (5-FU)1, 0.1 mL of 40 mg/mL TAC was added to 0.9 mL of 5-FU (50 mg/mL). This combination was injected weekly for 8 weeks. In Group 3, in addition to weekly TAC + 5-FU injection for 8 weeks, lesions were irradiated by 585-nm flashlamp-pumped pulsed-dye laser (PDL, 5-7.5 J/cm2) at the 1st, 4th, and 8th weeks. Lesions were assessed for erythema, pruritus, pliability, height, length, and width.RESULTS Sixty patients completed the study. At the 8- and 12-week follow-up visits, all groups showed an acceptable improvement in nearly all measures, but in comparison between groups, these were statistically more significant in the TAC + 5-FU and TAC + 5-FU + PDL groups (p<.05 for all)). At the end of the study, the erythema score was significantly lower, and itch reduction was statistically higher in the TAC + 5-FU + PDL group (p< .05 for both). Good to excellent improvements (>50 improvement) were reported by the patients as follows: 20 in Group 1, 55 in Group 2, and 75 in Group 3, all of which were significantly different (p<.05). Good to excellent responses were reported by the blinded observer as follows: 15 in Group 1, 40 in Group 2, and 70 in Group 3. Their differences were statistically significant (p<.05). Atrophy and telangiectasia were seen in 37 of patients in TAC group..CONCLUSION Overall efficacy of TAC + 5-FU was comparable with TAC + 5-FU + PDL, but the TAC + 5-FU + PDL combination was more acceptable by the patients and produced better results. Its effect on lightening of the lesion was promising. The TAC + 5-FU + PDL combination seems to be the best approach for treatment of keloid and hypertrophic scars..
|
| Descriptor
|
:
|
1. Skin Manifestations- drug therapy.- Descriptors: Keloid
|
|
|
:
|
Hypertrophy
|
|
|
:
|
Collagen
|
|
|
:
|
Dermatologic Agents
|
|
|
:
|
Triamcinolone
|
|
|
:
|
Lasers
|
|
|
:
|
Drug Combinations
|
| Added Entry
|
:
|
Asilian, Ali, Supervisor
|
| Translated Title Supplied by Cataloguer
|
:
|
مقایسه پاسخ بالینی کلوئید و اسکار هیپرتروفیک به سه ترکیب درمانی جدید
|
| | | | | |
| | |  |
http://elib.mui.ac.ir/site/catalogue/102630
| | | |
| | | |
|