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" New Combination Of Triamcinolone, 5-Fluorouracil, and Pulsed- Day Laser For the Treatment Of Keloid and Hypertrophic Scars. Afshin Darougheh "
/افشین داروغه
; Ali Asilian
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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102630
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| Doc. No
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T10405
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WR,143,D224n,2006
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| Main Entry
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Darougheh, Afshin
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| Title & Author
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New Combination Of Triamcinolone, 5-Fluorouracil, and Pulsed- Day Laser For the Treatment Of Keloid and Hypertrophic Scars. Afshin Darougheh/افشین داروغه
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| College
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Schools, Medical
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| Date
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, 2006
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| Degree
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Dermatology, Speciality
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no paging: ill, diag, tab
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| Note
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Orginal Works
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| Abstract
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BACKGROUND Keloids and hypertrophic scars are benign growths of dermal collagen that usually cause major physical, psychological, and cosmetic problems.METHODS In this 12-week single-blinded clinical trial, 69 patients were randomly assigned into three study groups. In Group 1, intralesional triamcinolone acetonide (TAC, 10 mg/mL) was injected at weekly intervals for a total of 8 weeks. In Group 2 ITAC + 5- fluorouracil (5-FU)1, 0.1 mL of 40 mg/mL TAC was added to 0.9 mL of 5-FU (50 mg/mL). This combination was injected weekly for 8 weeks. In Group 3, in addition to weekly TAC + 5-FU injection for 8 weeks, lesions were irradiated by 585-nm flashlamp-pumped pulsed-dye laser (PDL, 5-7.5 J/cm2) at the 1st, 4th, and 8th weeks. Lesions were assessed for erythema, pruritus, pliability, height, length, and width.RESULTS Sixty patients completed the study. At the 8- and 12-week follow-up visits, all groups showed an acceptable improvement in nearly all measures, but in comparison between groups, these were statistically more significant in the TAC + 5-FU and TAC + 5-FU + PDL groups (p<.05 for all)). At the end of the study, the erythema score was significantly lower, and itch reduction was statistically higher in the TAC + 5-FU + PDL group (p< .05 for both). Good to excellent improvements (>50 improvement) were reported by the patients as follows: 20 in Group 1, 55 in Group 2, and 75 in Group 3, all of which were significantly different (p<.05). Good to excellent responses were reported by the blinded observer as follows: 15 in Group 1, 40 in Group 2, and 70 in Group 3. Their differences were statistically significant (p<.05). Atrophy and telangiectasia were seen in 37 of patients in TAC group..CONCLUSION Overall efficacy of TAC + 5-FU was comparable with TAC + 5-FU + PDL, but the TAC + 5-FU + PDL combination was more acceptable by the patients and produced better results. Its effect on lightening of the lesion was promising. The TAC + 5-FU + PDL combination seems to be the best approach for treatment of keloid and hypertrophic scars..
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| Descriptor
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1. Skin Manifestations- drug therapy.- Descriptors: Keloid
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Hypertrophy
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Collagen
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Dermatologic Agents
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Triamcinolone
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Lasers
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Drug Combinations
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| Added Entry
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Asilian, Ali, Supervisor
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| Translated Title Supplied by Cataloguer
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مقایسه پاسخ بالینی کلوئید و اسکار هیپرتروفیک به سه ترکیب درمانی جدید
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