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" Detrmination of relative frequency of H. Pylori Seropositivity in cirrhotic patients with encephalopathy and without encephalopathy place Saint Al-Zahra Medical Centre & Noor Medical Hospital "
/شادان اختر
; Ahmad Shavakhi
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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102668
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| Doc. No
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T10966
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| Call number
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WI,700,A315d,2007
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| Main Entry
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Akhtar, Shadan
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| Title & Author
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Detrmination of relative frequency of H. Pylori Seropositivity in cirrhotic patients with encephalopathy and without encephalopathy place Saint Al-Zahra Medical Centre Noor Medical Hospital/شادان اختر
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| College
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Schools, Medical
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| Date
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, 2007
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| Degree
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Medicine, MD
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| Page No
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51 p.: diag, tab
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| Note
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Orginal Works
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| Abstract
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Background: Hepatic encephalopathy (HE) is a common and serious complication affecting patients with liver disease. There are various mechanism for etiopathogenesis of hepatic encephalopathy. Ammonia is the substance most often incriminated in the pathogenesis of encephalopathy. Ammonia levels increase as liver function declines and decrease with the treatment. Most of the ammonia is of gut origin where it is produced by the bacterial flora. Stomach when infected with H.pylori is an alternative site of ammonia production. Normally the liver extracts the ammonia, therefore, in liver failure large quantities reach the systemic criculation because of portosystemic shunting and impaired ureagenesis. H. pylori infection could theoretically contribute to development or deterioration of encephalopathy. Methods: In this case control study, we measured the anti H. pylori IgG antibody in 36 cirrhotic patients (18 hepatitis B and 18 hepatitis C; mean age =48 ▒ 11; 22 men, 14 women) presenting with encephalopathy and were admitted to the hospital and 100 cirrhotic patients with same etiology (49 hepatitis B case and 51 hepatitis C; mean age = 44 ▒ 14;.76 men , 24 women) without encephalopathy . Child score and presence of previous episodes of overt HE were recorded. Diagnosis of cirrhosis was determined according to clinical, laboratory and / or Histopatholoic tfindings. Diagnosis of encephalopathy was made based on clinical assessment (mental status, complaints of sleep pattern disturbance, and psychometric testing). Results: Anti تH pylori IgG antibody was present in 70 of patients with encephalopathy and 52 of control (p< 0.05) .There was no statistical association between " antibody status and child score, and number of encephalopathy episodes. Discussion and conclusion: The relative seroprevalence of anti H pylori IgG was found to be higher in patients with cirrhosis due to HBV and HCV with encephalopathy compared to controls. These differences cannot be explained with difference in socioeconomic condition, because hospital is open to every one. Key words: Hepatic Encephalopathy Helicobacter pylori Cirrhosis.
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| Descriptor
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1.Hepatic Encephalopathy.- Descriptors: Helicobacter Pylori
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Hepatic Encephalopathy
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Fibrosis
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Brain Edema
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Cerebrovascular Disorders
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| Added Entry
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Shavakhi, Ahmad, supervisor
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