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" Topical Finasteride in hirsutism. Samira karbasioun "
/سمیرا کرباسیون
; Fariba Irajii, Asharf Aminorraya
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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102703
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| Doc. No
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T11285
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| Call number
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WR,455,k18t,2004
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| Main Entry
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Karbasioun, Samira
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| Title & Author
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Topical Finasteride in hirsutism. Samira karbasioun/سمیرا کرباسیون
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| College
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Schools, Medical
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| Date
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, 2004
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| Degree
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Dermatology, Speciality
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| Page No
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14 p.
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| Note
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This thesis is also a research project with project ID 82142
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| Note
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Orginal Works
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| Abstract
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Background: Finasteride partially blocks the conversion of test(Nerone to dinrotestosterone through inhibition of 5a- reductase in hair follicles. I inaster:Je cream can penetrate to dermis to arrive at hair follicle due to its solubility. Theref: 7e. it is expected to be used in treatment of hirsutism with less systemic adverse effects. This study was designed to determine the efficacy of finasteride cream 0.5?0 in management of idiopathic hirsutism. Methods: Finasteride (0.5 ) and placebo creams were administered to 35 women with hirsutism on the face. Medication and placebo creams each one was used on opposite sides of the face in an area of excessive hair growth, not necessarily symmetrical. The side chosen for the finasteride cream versus placebo was randomized and blinded in a 1 cm2 area on each side of the face. Hair numbers were counted and the thickness of all hairs was also measured by micrometer and their mean was calculated, at the start of therapy and after 6 months. Statistical analysis was done in SPSS software using Paired and Student T-tests. P-values less than 0.05 were considered significant. Results: The mean of hair numbers decreased at placebo-applied side from 12.20 ▒ 6.15 to 10.50 + 4.90 (P<0.001) and at finasteride- treated side from 11.37 ▒ 6.15 to 8.47 ▒ 4.62 (P<0.001). Mean of hair thickness at placebo side decreased 2.92 ▒ 0.84 pm to 2.72+ 0.79 pm (P<0.001) and at finasteride side from 3.17 ▒ 0.95, to 2.37▒0.79 (P<0.001). Comparison of hair number and thickness showed no statistically significant changes in finasteride versus placebo treated sides. But, according to patients' view points, hair growth rate was diminished and hair was looser on finasteride treated side. Conclusion: Six months of topically applied finasteride (0.5 ) does not affect on number and thickness of facial hirsutism significantly. Despite lack of objective changes, on questioning, most patients in finastride group perceived a decrease with time in hair growth. Keywords: Finasteride- Cream- Hirsutisrn.rotestosterone through inhibition of 5a- reductase in hair follicles. I inaster:Je cream can penetrate to dermis to arrive at hair follicle due to its solubility. Theref: 7e. it is expected to be used in treatment of hirsutism with less systemic adverse effects. This study was designed to determine the efficacy of finasteride cream 0.5?0 in management of idiopathic hirsutism. Methods: Finasteride (0.5 ) and placebo creams were administered to 35 women with hirsutism on the face. Medication and placebo creams each one was used on opposite sides of the face in an area of excessive hair growth, not necessarily symmetrical. The side chosen for the finasteride cream versus placebo was randomized and blinded in a 1 cm2 area on each side of the face. Hair numbers were counted and the thickness of all hairs was also measured by micrometer and their mean was calculated, at the start of therapy and after 6 months. Statistical analysis was done in SPSS software using Paired and Student T-tests. P-values less than 0.05 were considered significant. Results: The mean of hair numbers decreased at placebo-applied side from 12.20 ▒ 6.15 to 10.50 + 4.90 (P<0.001) and at finasteride- treated side from 11.37 ▒ 6.15 to 8.47 ▒ 4.62 (P<0.001). Mean of hair thickness at placebo side decreased 2.92 ▒ 0.84 pm to 2.72+ 0.79 pm (P<0.001) and at finasteride side from 3.17 ▒ 0.95, to 2.37▒0.79 (P<0.001). Comparison of hair number and thickness showed no statistically significant changes in finasteride versus placebo treated sides. But, according to patients' view points, hair growth rate was diminished and hair was looser on finasteride treated side. Conclusion: Six months of topically applied finasteride (0.5 ) does not affect on number and thickness of facial hirsutism significantly. Despite lack of objective changes, on questioning, most patients in finastride group perceived a decrease with time in hair growth. Keywords: Finasteride- Cream- Hirsutisrn.rotestosterone through inhibition of 5a- reductase in hair follicles. I inaster:Je cream can penetrate to dermis to arrive at hair follicle due to its solubility. Theref: 7e. it is expected to be used in treatment of hirsutism with less systemic adverse effects. This study was designed to determine the efficacy of finasteride cream 0.5?0 in management of idiopathic hirsutism. Methods: Finasteride (0.5 ) and placebo creams were administered to 35 women with hirsutism on the face. Medication and placebo creams each one was used on opposite sides of the face in an area of excessive hair growth, not necessarily symmetrical. The side chosen for the finasteride cream versus placebo was randomized and blinded in a 1 cm2 area on each side of the face. Hair numbers were counted and the thickness of all hairs was also measured by micrometer and their mean was calculated, at the start of therapy and after 6 months. Statistical analysis was done in SPSS software using Paired and Student T-tests. P-values less than 0.05 were considered significant. Results: The mean of hair numbers decreased at placebo-applied side from 12.20 ▒ 6.15 to 10.50 + 4.90 (P<0.001) and at finasteride- treated side from 11.37 ▒ 6.15 to 8.47 ▒ 4.62 (P<0.001). Mean of hair thickness at placebo side decreased 2.92 ▒ 0.84 pm to 2.72+ 0.79 pm (P<0.001) and at finasteride side from 3.17 ▒ 0.95, to 2.37▒0.79 (P<0.001). Comparison of hair number and thickness showed no statistically significant changes in finasteride versus placebo treated sides. But, according to patients' view points, hair growth rate was diminished and hair was looser on finasteride treated side. Conclusion: Six months of topically applied finasteride (0.5 ) does not affect on number and thickness of facial hirsutism significantly. Despite lack of objective changes, on questioning, most patients in finastride group perceived a decrease with time in hair growth. Keywords: Finasteride- Cream- Hirsutisrn..
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| Descriptor
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1. Hirsutism.- Descriptors: Hirsutism- drug therapy
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Placebos
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Finasteride
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Prescriptions, Drug
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| Added Entry
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Irajii, Fariba, Supervisor
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Aminorraya, Asharf, Supervisor
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