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" Evalution of magnesium Sulfate on morbidity of Stroke. Mohammad Saadatnia "
/محمد سعادتنیا
; Ali Mousavi
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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102706
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| Doc. No
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T11286
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WL,355,S124e,2003
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| Main Entry
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Saadatnia, Mohammad
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| Title & Author
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Evalution of magnesium Sulfate on morbidity of Stroke. Mohammad Saadatnia/محمد سعادتنیا
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| College
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Schools, Medical
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| Date
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, 2003
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| Degree
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Neurology, Speciality
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This thesis is a also a research project with project ID 80292
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42 p.: tab
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| Note
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Orginal Works
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| Abstract
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Introduction: Administration of magnesium sulfate has neuroprotective effects and reduces infarct volume in animal models of stroke. Previous small clinical trials have reported beneficial effect of magnesium on the outcome in patients with stroke. Methods: This study was a randomized, placebo-controlled, double-blind study was investigated the benefit of the administration of magnesium sulfate given intravenously as a neuroprotective and effect of magnesium on reduction of siezure in acute phase of stroke. Patients who had cortical infarction in the middle cerebral artery territory (superior or inferior division) with moderat( neurologic deficits (Orgogozo scale score greater than 30 and less than 70) and onset less than 24 hours were included. The patients were treated with magnesium sulfate (4gr stat and lgr/hr) or placebo for 4 days and examine( by a blind investigator. NIH Stroke Scale was obtained on admission and day 5 after stroke. Results: 18 patients given treatment and 19 patients given placebo demonstrated significant beneficial effects on the difference in NIH Stroke Scale on the day of admission and day 5 (3.16+/-0.98 vs 1.84+/-1.06 p < 0.000) respectively. Conclusion: Intravenous magnesium sulfate had significant beneficial effect on acute phase of stroke patients and as a result may be reduces duration of admission. Further investigation is needed to confirm and complete these findings. key word: Stroke, Magnesium sulfate, Neuroprotective.
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| Descriptor
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1. Cerebrovascular Disorders.- Discriptors: Cerebrovascular Disorders- mortality
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Cerebrovascular Accident
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Magnesium Sulfat- administration dosage
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Placebos
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Neuroprotective Agents
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| Added Entry
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Mousavi, Ali, Supervisor
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