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" Evaluation of topical insulin effect on neuropathic diabetic foot ulcer healing. Alireza Najafian, Mehdi Torki "
/علیرضا نجفیان، مهدی ترکی
; Mansour Siavash
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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102710
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| Doc. No
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T11372
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WK,835,N162e,2008
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| Main Entry
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Najafian, Alireza
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| Title & Author
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Evaluation of topical insulin effect on neuropathic diabetic foot ulcer healing. Alireza Najafian, Mehdi Torki/علیرضا نجفیان، مهدی ترکی
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| College
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Schools, Medical
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| Date
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, 2008
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| Degree
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Medicine, MD
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| Page No
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48 P.: ill
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This thesis a also a research project with project ID 385184
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Orginal Works
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| Abstract
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Introduction: Foot problem is an important cause of morbidity in patients with diabetes mellitus. Both vascular and neurologic diseases contribute to this problem. It is estimated, as an example, that the prevalence of diabetic neuropathy in patients with type 2 diabetes is 32 percent overall and more than 50 percent in patients over 60 years of age. Standard measures for diabetic foot ulcer (off-loading, infection control, improve blood supply and debridment) are not effective enough in diabetic foot ulcers' healing. Several novel approaches have been reported that may improve ulcer healing. Insulin is one of the primary anabolic hormones in the body, and numerous studies have shown beneficial effects of insulin therapy on wound healing.Goal: Evaluation of topical insulin effect on neuropathic diabetic foot ulcer healing. Materials and methods: This study is an analytical, clinical trial, case control research. Patients with neuropathic foot ulcers, resistant to standard treatment for more than 6 months were entered the study and considered as controls. Standard treatment of diabetic foot ulcers includes infection control, improvement of blood supply, debridment, and off-loading. Topical insulin is made of water based gel containing 40 IU of NPH insulin per milliliter. Patients were educated to apply this gel on the ulcer everyday after washing of ulcer with 1 liter of normal saline washing serum. In this method, patients were visited with twice a week for debridment and assessment of ulcer conditions. Results: Duration of ulcers without healing was 11.76+5.10 months and for our method was 2.11+0.84 months. (P-value <0.000) Discussion: Insulin has an important role in metabolism, protein synthesis, cell growth and cell differentiation, which suggest the important role of this hormone in control and regulation of ulcer healing. Insulin is a PDGF (Platelet derived growth factor) and EGF (Epidermal growth factor) synergist, increases granulation tissue and improves collagen sedimentation. Then, insulin can improve the wound healing. Conclusion:Our research demonstrated that topical insulin is significantly effective in healing of neuropathic diabetic foot ulcers. Key Words: Insulin, diabetes mellitus, diabetic foot, ulcer, foot ulcer, topical insulin.
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| Descriptor
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1. Diabetic Foot.- Descriptors: Insuline
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Diabetic Foot
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Ulcer
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Evaluation Studies
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Torki, Mehdi, Author
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Siavash, Mansour, Supervisor
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| Translated Title Supplied by Cataloguer
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بررسی تاثیر انسولین موضعی در بهبود زخم نروپاتیک پای دیابتی
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