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" Evaluation the effect of glucose- insulin- potassium infusion( GIK ) accompanied by thrombolytic therapy on mortality rates of diabetic patients with acute myocardial infarction. Afshin Amirpour, Reyhaneh Zavar "
/افشین امیرپور، ریحانه زوار
; Ali Pourmoghadas, Masoud Amini, Masoud Pourmoghadas
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Isfahan University of Medical Sciences
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Latin Dissertation
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English
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| Record Number
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102718
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| Doc. No
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T11476
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WG,300,A517e
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| Main Entry
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Amirpour, Afshin
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| Title & Author
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Evaluation the effect of glucose- insulin- potassium infusion( GIK ) accompanied by thrombolytic therapy on mortality rates of diabetic patients with acute myocardial infarction. Afshin Amirpour, Reyhaneh Zavar/افشین امیرپور، ریحانه زوار
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| College
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Schools, Medical
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, [138- ]
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Cardiology, Speciality
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[ Not Pagings ], tab
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Orginal Works
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| Abstract
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INTRODUCTION: In spite of the current methods of treatment, acute myocardial infarction (AMI) is still associated with high mortality and morbidity rates, especially in diabetic patients. Recent studies have demonstrated the value of glucoseinsulin-potassium (01K) infusion accompanied by thrombolytic therapy in meeting the aforesaid objectives with statistically meaningful results. Methods: This is a two-year case-control prospective trial involving 300 patients referring to the internal medicine emergency services of Chamran and Nour Hospitals. Thrombolytic therapy was indicated for all of these patients. The patients were divided into case and control groups. The case group comprised patients with acute myocardial infarction who were treated with high doses of GIK accompanied by thrombolytic at the same time. The control group consisted of patients with acute myocardial infarction who were treated only with thrombolytic agent. Upon admission and until 6 months after discharge, the patients were examined and followed up by two cardiology residents cooperating with the study in respect of physical findings and cardiac arrhythmias. The patients underwent echocardiography upon discharge and six months later. Results: Cardiac arrhythmia during hospitalization was seen in 13.3 of patients in the case group (treated with GIK and thrombolytic agent) and 24.3 of patients in the control group Mortality rate during the six-month follow-up period was 4.9 in the case group and 12.6 in the control group (P=0.02). Mean ejection fraction of patients before discharge was 44=9.6 in the case group and 40=9.8 in the control group. (P=0.00) Mean ejection fraction after Six months measured 46=8 in the case group and 41.519.6 in the control group. (P=0.00). Discussion: This study demonstrated that early infusion of high dose of GIK accompanied by thrombolytic agent can have a wide range of beneficial effects in the treatment of diabetic patients with acute myocardial infarction. This, method of treatment does not require specialized training or technology; it is associated with few side-effects and leads to a reduction in the frequency of important clinical events such as death and ventricular arrhythmia Keywords: Acute myocardial infarction, Diabetes mellitus, GIK (Glucose-Insulin-potassium).
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| Descriptor
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1. Myocardial Infraction.- Descriptors: Myocardial Infraction
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Thrombolytic Therapy
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Diabetic Angiogiopathies
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Glucose
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Potassium
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Insulin
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Risk Factors
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Cardiovascular Diseases
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Zavar, Reyhaneh, Relator
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Pourmoghadas, Ali, Supervisor
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Amini, Masoud, Supervisor
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Pourmoghadas, Masoud, Supervisor
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