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" The correlation pathological findings in biopsy and first clinical and laboratory manifestions of focal and semental glomerulosclerosis. Pargol Samanianpour "
/پرگل سامانیانپور
; Diana Taheri, Shiva Seirafian
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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102721
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| Doc. No
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T11478
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WJ,353,S635c,2008
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| Main Entry
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Samanianpour, Pargol
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| Title & Author
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The correlation pathological findings in biopsy and first clinical and laboratory manifestions of focal and semental glomerulosclerosis. Pargol Samanianpour/پرگل سامانیانپور
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| College
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Schools, Medical
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| Date
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, 2008
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| Degree
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Medicine, MD
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55 p.: ill, diag, tab
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| Note
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This thesis is also a research project with project ID 386113
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Orginal Works
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| Abstract
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Background: The first clinical presentations and morphologic features of FSGS are various among patients and they are important predictor of prognosis in them. The aim of this study was to analyze the correlation of clinical, laboratory and pathological features at presentation of FSGS.Methods: In this cross-sectional study, pathological findings of 64 cases of primary FSGS were reviewed by single renal pathologist without knowledge of patient identity or outcome. Clinical and laboratory data will be obtained on each patient at the time of biopsy. The data include systolic and diastolic blood pressure, the level of plasma creatinine, BUN, glomerular filtration rate (GFR), serum albumin, and the level of proteinuria. Then compare histopathological findings with clinical and laboratory data at the time of biopsy.Results: The mean of Serum creatinin level was significantly higher in the patients with the presence of synechiae with the Bowman's capsule, and the presence of interstitial fibrosis and the presence of the global scars in their biopsies(p value < 0.05), and also there were significant different in the mean level of GFR in the patients with the presence of interstitial fibrosis in their biopsies in the comparison with the patients without the interstitial fibrosis (p value < 0.05).Also we discovered positive correlation between the level of plasma creatinin and global sclerosis(r=2,21 ,p-value=0.04),and between the level of GFR and global sclerosis(r= 2.01 ,p-value=0.02). All the patients with renal insufficiency had intrestial fibrosis in their biopsies in comparison of only the 24 patients (48 ) of the group without renal insufficiency (p value < 0.05). There were no significant difference between patients with and without hypertension and nephrotic- ranged proteinuria.Conclusion: in our studies we found that in addition to the interstitial fibrosis, global scars and the synechiae of Bowman's capsule are correlated with serum creatinin level and the level of plasma albumin and GFR.Although the prognostic role of these laboratories and the pathological features have not been proved until now, but because ..the prognostic role of the laboratory findings such as Pcr which is correlated with these pathological features, has been proved ,there is a hypothesis that these two pathological features could have prognostic roles in FSGS patients.
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| Descriptor
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1. Glomerulonephritis.- Descriptors: Glomerulonephritis
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Glomerulosclerosis, Focal Segmental
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Kidney function Tests
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Creatinine
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Biopsy
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Prognosis
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Kidney Failure, Chronic- pathology
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| Added Entry
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Taheri, Diana, Supervisor
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Seirafian, Shiva, Supervisor
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| Translated Title Supplied by Cataloguer
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ارتباط یافتههای پاتولوژیکی در بیوپسی کلیه با نخستین تظاهرات بالینی و آزمایشگاهی در بیماران مبتلا به بیماری فوکال سگمنتال گلومرلواسکلروزیز اولیه
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