|
" Evaluation of neuroprotective effect of dextromethorphan in acute phase of ischemic strok during the years of 2007-2008 in Al-Zahra Hospital of Isfahan University of Medical Scince. Payam Sariaslani "
/پیام ساریاصلانی
; Mohammad Saadatnia, Ali Mousavi
| center
|
:
|
Isfahan University of Medical Sciences
|
| Document Type
|
:
|
Latin Dissertation
|
| Language of Document
|
:
|
English
|
| Record Number
|
:
|
102723
|
| Doc. No
|
:
|
T11400
|
| Call number
|
:
|
WL,355,S245e,2008
|
| Main Entry
|
:
|
Sariaslani, Payam
|
| Title & Author
|
:
|
Evaluation of neuroprotective effect of dextromethorphan in acute phase of ischemic strok during the years of 2007-2008 in Al-Zahra Hospital of Isfahan University of Medical Scince. Payam Sariaslani/پیام ساریاصلانی
|
| College
|
:
|
Schools, Medical
|
| Date
|
:
|
, 2008
|
| Degree
|
:
|
Neurology, Speciality
|
| Page No
|
:
|
III, 35 p.:; diag, tab
|
| Note
|
:
|
This thesis is also a research project with project ID 385562
|
| Note
|
:
|
Orginal Works
|
| Abstract
|
:
|
Introduction: Administration of dextromethorphan has neuroprotective effects and reduces infarct volume in animal models of stroke. This is the first clinical trial to evaluate neuroprotective effect of dextromethorphan in stroke patients. Methods: This study was a randomized, placebo-controlled ,double-blind study was investigated the benefit of the administration of oral dextromethorphan given as a neuroprotective in acute phase of stroke. Patients who had cortical infarction in the middle cerebral artery territory (stem, superior and inferior or deep division) with moderate neurologic deficits (NIHSS 8-16) and onset less than 24 hours were included. The patients were treated with dextromethorphan (60mg stat and 300mg/24hr) or placebo for 5 days and examined by a blind investigator. NIH Stroke Scale was obtained on admission and day 5 after stroke. Barthel and modified Rankin scale was obtained on 90 days. Results: In comparison between two groups (20 patients given treatment and 20 patients given placebo) demonstrated no significant beneficial effects on the difference in NIH Stroke Scale on the day of admission and day 5, and Barthel and modified Rankin scale son 90 days. Conclusion: Dextromethorphan had no significant beneficial effect on stroke patients and further investigation is needed to confirm and complete these findings. Key word: Stroke, dextromethorphan, Neuroprotective.
|
| Descriptor
|
:
|
1. Cerebral Infarction.-Descriptors: Cerebral Infarction- drug therapy
|
|
|
:
|
Cerebreal Arteries
|
|
|
:
|
Dextromethorphan
|
|
|
:
|
Cerebrovascular Accident
|
| Added Entry
|
:
|
Saadatnia, Mohammad, Supervieor
|
|
|
:
|
Mousavi, Ali, Supervisor
|
| Translated Title Supplied by Cataloguer
|
:
|
اثر نروپروتکتیو دکسترومتورفان در بیماران مبتلا به سکته مغزی
|
| |