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" Study of the interaction between hormone replacement therapy and A1730G genotypes of estrogen receptor B on quantitative variation in lipoproteins, apolipoproteins and ATP binding cassette A1 ( ABCA1 ) gene expression in postmenopausal women. Maryam Darabi "
/مریم دارابی
; Mohsen Ani, Mohammed Rabbani, Mojtaba Panjehpour, Ahmad Movahedian, Elahe Zarean
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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English
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| Record Number
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102794
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| Doc. No
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T12391
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WP,522,D213s,2010
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| Main Entry
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Darabi, Maryam
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| Title & Author
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Study of the interaction between hormone replacement therapy and A1730G genotypes of estrogen receptor B on quantitative variation in lipoproteins, apolipoproteins and ATP binding cassette A1 ( ABCA1 ) gene expression in postmenopausal women. Maryam Darabi/مریم دارابی
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| College
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Schools, Pharmacy
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| Date
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, 2010
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| Degree
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Clinical Biochemistry, Ph.D
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| Page No
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94, XIII p.: diag., tab
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| Note
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This thesis is also a resesarch project with project ID 388149
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Orginal Works
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| Abstract
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introduction: Postmenopausal hormone replacement therapy (HRT) is known to affect various aspects of lipoprotein metabolism. The estrogen receptor p (ER13) mediates the action of estrogen on the lipids and lipoproteins metabolism. The aim of the present study was to investigate whether the ERI3 A 1730G polymorphism modifies ABCA1 gene expression and metabolic responses to HRT in postmenopausal women.Materials and Methods: The population included 60 normoIipidemic postmenopausal women with the diffewit genotypes (20-GG. 20 GA. and 20 AA) assigned to 90-day hormone replacement therapy. The ERB genotype. ABCA I gene expression. oxidative status and lipid profile were determined respectively. by PCR-RFLP analysis, real-time PCR, FRAP. and ELI SA methods.Results: Analysis of leukocytes ABCA I rriRNA showed a significant increase in ABCA! gene expression after the postmenopausal HRT (P--0.0011). After the postmenopausal HRT. subjects with GG genotype had greater increase in ARCA I (P=0.002) than subject carrying A allele. Postmenopausal HRT led to significant increase in TAC (15 . P=0.02). There was no significant relationship between oxLDL/B2GPI complexes. TAC levels and leukocytes ABCA I gene expression even after adjustment for confounding factors.Conclusion: The beneficial cardiovascular effects of postmenopausal HRT could beexplained, at least in part, by increasing the ABCAI gene expression and improving.
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| Descriptor
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1. Estrogen Replacement Therapy.- Descriptors: Estrogen Replacement Therapy
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Menopause
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Genotype
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Estrogen Receptor beta
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Adenosine Triphosphate
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Lipoproteins
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Gene Expression
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Ani, Mohsen, Supervisor
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Panjehpour, Mojtaba, Supervisor
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Movahedian, Ahmad, Supervisor
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Zarean, Elahe, Supervisor
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| Translated Title Supplied by Cataloguer
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بررسی اثر متقابل هورمون درمانی ( ( HRT و ژنوتیپهای A1730G رسپتور B استروژن بر تغییرات کمی لیپوپروتئینی، آپولیپوپروتئینی و بیان ژن ABCA1 در زنان یائسه
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