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center : Isfahan University of Medical Sciences
Document Type : Latin Dissertation
Language of Document : English
Record Number : 102794
Doc. No : T12391
Call number : ‭WP,522,D213s,2010‬
Main Entry : Darabi, Maryam
Title & Author : Study of the interaction between hormone replacement therapy and A1730G genotypes of estrogen receptor B on quantitative variation in lipoproteins, apolipoproteins and ATP binding cassette A1 ( ABCA1 ) gene expression in postmenopausal women. Maryam Darabi/مریم دارابی
College : Schools, Pharmacy
Date : , 2010
Degree : Clinical Biochemistry, Ph.D
Page No : 94, XIII p.: diag., tab
Note : This thesis is also a resesarch project with project ID 388149
Note : Orginal Works
Abstract : introduction: Postmenopausal hormone replacement therapy (HRT) is known to affect various aspects of lipoprotein metabolism. The estrogen receptor p (ER13) mediates the action of estrogen on the lipids and lipoproteins metabolism. The aim of the present study was to investigate whether the ERI3 A 1730G polymorphism modifies ABCA1 gene expression and metabolic responses to HRT in postmenopausal women.Materials and Methods: The population included 60 normoIipidemic postmenopausal women with the diffewit genotypes (20-GG. 20 GA. and 20 AA) assigned to 90-day hormone replacement therapy. The ERB genotype. ABCA I gene expression. oxidative status and lipid profile were determined respectively. by PCR-RFLP analysis, real-time PCR, FRAP. and ELI SA methods.Results: Analysis of leukocytes ABCA I rriRNA showed a significant increase in ABCA! gene expression after the postmenopausal HRT (P--0.0011). After the postmenopausal HRT. subjects with GG genotype had greater increase in ARCA I (P=0.002) than subject carrying A allele. Postmenopausal HRT led to significant increase in TAC (15 . P=0.02). There was no significant relationship between oxLDL/B2GPI complexes. TAC levels and leukocytes ABCA I gene expression even after adjustment for confounding factors.Conclusion: The beneficial cardiovascular effects of postmenopausal HRT could beexplained, at least in part, by increasing the ABCAI gene expression and improving.
Descriptor : 1. Estrogen Replacement Therapy.- Descriptors: Estrogen Replacement Therapy
: Menopause
: Genotype
: Estrogen Receptor beta
: Adenosine Triphosphate
: Lipoproteins
: Gene Expression
Added Entry : Ani, Mohsen, Supervisor
: Panjehpour, Mojtaba, Supervisor
: Movahedian, Ahmad, Supervisor
: Zarean, Elahe, Supervisor
Translated Title Supplied by Cataloguer : بررسی اثر متقابل هورمون درمانی ( ‭( HRT‬ و ژنوتیپ‌های ‭A1730G‬ رسپتور B استروژن بر تغییرات کمی لیپوپروتئینی، آپولیپوپروتئینی و بیان ژن ‭ABCA1‬ در زنان یائسه
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Study of the interaction between hormone replacement ther...
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