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" Efficacy Evaluation of Mycophenolate Mofetil (Cellcept) in Combination with IFNB- 1a (Cinnovex) in Multiple Sclerosis Patients in Isfahan "


center : Isfahan University of Medical Sciences
Document Type : Latin Dissertation
Language of Document : English
Record Number : 102811
Doc. No : T12572
Call number : ‭WL,360,K23e,2010‬
Main Entry : Kazemi, Mojtaba
Title & Author : Efficacy Evaluation of Mycophenolate Mofetil (Cellcept) in Combination with IFNB- 1a (Cinnovex) in Multiple Sclerosis Patients in Isfahan/مجتبی کاظمی
College : Schools, Medical
Date : , 2010
Degree : Neurology, Speciality
Page No : IX, 65 p.: ill, diag, tab
Note : This thesis is also a research project with project ID 388374
Note : Orginal Works
Abstract : Background & Aims: We evaluated the efficacy of Mycophenolate mofetil (MMF) plus interferon beta-1 a (IENB-1 a) in treatment of relapsing-remitting multiple sclerosis (RRMS). Methods & Materials: This was a pilot study with randomized, double-blinded, placebo-controlled design. Patients with RRMS and Expanded Disability Status Scale score EDSS) of <6.0 were included. Those with relapse within the previous two months and prior use of immunomodulatory/immunosuppressive drugs were excluded. Patients were randomized into MMF (n=13) and placebo (n=13) groups and received weekly intramuscular IFNB-1 a plus either MMF or placebo. MMF started by 500 mgld for one week and weekly escalated by 500 mg/d, until target divided dose of 2000 mg/d and continued for 12 months. Radiologic and clinical assessments were performed at baseline and then at month 12. Data were analyzed with SPSS version 16.0, using Student's t-test, chi-squared test, and multivariate analyses. Results: After one year of therapy, difference between the two groups in number of new T2 lesions was not statistically significant (0.54-10.77 in MMF vs. 1.85▒3.2 in placebo group, p=0.169). Two patients in the placebo group had gadolinium-enhanced lesions and one patient had relapse. There were 3 patients in each group with more than one point progression in EDSS. Common side effect in the MMF group included gastrointestinal upset, but no patient discontinued the treatment. Conclusions: Combination of MMF with IFNB-la in patients with RRMS is well tolerated, but the efficacy of such combination in this pilot study was not statistically significant and deserves further investigation with larger sample size and longer follow-up..
Descriptor : 1. Mulitiple Sclerosis .- Descriptors: Mulitiple Sclerosis
: Mycophenolic Acid
: Interferon-beta
: Immunosuppressive Agents
: Multiple Sclerosis, Relapsing-Remitting
Added Entry : Etemadifar, Masoud, Supervisor
: Chitsaz, Ahmad, Supervisor
Translated Title Supplied by Cataloguer : بررسی اثر درمانی ترکیب سل سپت و اینترفرون در بیماران مبتلا به ‭MS‬
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