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" The Assessment of statins effect on standard antiviral treatment response in hyoerlipidemic genotype I HCV patients who have been referred to educational and therapeutic centers of Isfahan University of Medical Sciences from 2009 till 2010 "
/ناصر خمیسی
; Ahmad Shavakhi
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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102886
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| Doc. No
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T13119
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| Call number
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WC,536,K45a,2010
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| Main Entry
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Khamisi, Naser
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| Title & Author
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The Assessment of statins effect on standard antiviral treatment response in hyoerlipidemic genotype I HCV patients who have been referred to educational and therapeutic centers of Isfahan University of Medical Sciences from 2009 till 2010/ناصر خمیسی
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| College
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Schools, Medical
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| Date
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, 2011
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| Degree
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Gastroenterology and Liver Disease, Specialty
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| Page No
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71 p.: diag, tab
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| Note
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This thesis is also a research project with project ID 309079
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| Note
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Orginal Works
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| Abstract
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to assess the effect of statins in ocmbination with standard antiviral treatment on hyperlipidemic genotype I HCV patients who had been referred to educational and therapeutic centers of isfahan university of medical sciences from 2009-2010. our study was a prospective clinical trial. all samples(n= 40) were tested to confirm HCV viremia cobas amplicor HCV monitor test, version 2. all patients weekly received 180 ug PEG- INFa2a and 1000, 1200 and 1400 mg RBV for weights < 75 kg, 75-100 kg and more than 100 kg respertively. case samples( n=20) ( hyperlipidemic patients) received 20 mg atorvastatin (farabi co) nightly for three months and placebo was prescribe for control patients(n=20) same as atorvastatin in case group. liver enzymes, CBC were checked monthly and TSH checked every three months. wa also did quantitive HCV-RNA test in 12th week of therapy, at the end of treatment and 6 months after therapy for all samples. we did not and find any significant difference in the mean of HCV- RNA numbers in case and control groups in 12th week of treatment, in the end of treatment and 6 months after treatment. in this study early response to treatment(EVR) in case and control were 80 and 70 and end point of treatment in case and control was 90 and 95 respectively. SVR in case and control of both were 95 . there was no effect of statins on the mean of HCV virus number in this analysis. further studies are necessary to examine the possible antiviral properties of statins and their potential role as adjuncts to standard HCV therapy..
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| Descriptor
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1.Hepatit C.- Descriptors: Hepatit C
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Astatine
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Lipids
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| Added Entry
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Shavakhi, Ahmad, Supervisor
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| Translated Title Supplied by Cataloguer
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بررسی اثر استاتین بر میزان پاسخ ویرولوژیک درمان استاندارد در بیماران مبتلا به هپاتیت C مزمن ژنوتیپ یک و هیپرلیپدمیک در بیمارن مراجعه کننده به مراکز فوق تخصصی درمانی و آموزشی دانشگاه علوم پزشکی اصفهان در سال۱۳۸۸-۱۳۸۹
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