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" Evaluation of frequency of CD10 expression and its assoviation with depth of invasion (Clark levels) and tumor thickness according to Breslow in primary malignant melanoma "
/شیلا شریعت
; Parvin Rajabi
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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102907
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| Doc. No
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T13052
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| Call number
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QZ,200,S531e,20101390/10/15
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| Main Entry
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Shariat, Sheila
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| Title & Author
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Evaluation of frequency of CD10 expression and its assoviation with depth of invasion (Clark levels) and tumor thickness according to Breslow in primary malignant melanoma/شیلا شریعت
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| College
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Schools, Medicine
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| Date
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, 2010
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| Degree
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Clinical and anatomical pathplogy, Ph.D
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| Page No
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h.43p.: Table, Graph
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| Note
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This thesis is also a research project with project ID 388445
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| Abstract
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Melanoma accounts for only 4 percent of all skin cansers, however, it causes the greatest number of skine canser related deaths worldwide.Possible association of the CD10 expression with progression of melanoma has been suggested. Our objective in this study was to determine frequency of CD10 expression and its assoviation with depth of invasion high depth levels and tumor thickness according to Breslow in primary malignant melanoma. This was retrospective study that was performed in St- Alzahra hospital, Isfahan in 1388-1389. 40 paraffinembedded section with confirmed diagnosis of primary melanoma were selected randomly and evaluate for association between the low versus highClark index and Breslow index with the H-Scote of CD10 expression. The dTA WERE ANALYZED USING spss VER15.00 and statistical tests including t-test, Chi- squar and spearman correlation. 90 percent of section showed positive results for CD10 expression. there was significant association between H-score and Breslow index and high Clark level (p=0/000).our results were consistent with previos results. To better evaluate the frequency of CD10 expression in melanoma, more extensive studies are recommended.
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| Descriptor
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1. Melanoma.- Descriptors: Melonama
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Gene Expression
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Skin Neoplasms- pathology
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Neprilysin
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| Added Entry
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Rajabi, Parvin, Supervisor
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siadat, Amir Hossein, Supervisor
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