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" An immunohistocal study of HER-2/ neu expression in mennigioma and its correlation with tumor grade "
/محمد موحدی پور
; Parvin Mahzoni
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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102910
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| Doc. No
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T13338
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QZ,380,M935,2012
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| Main Entry
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Movahedipour, Mohammad
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| Title & Author
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An immunohistocal study of HER-2/ neu expression in mennigioma and its correlation with tumor grade/محمد موحدی پور
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| College
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Schools, Medical
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| Date
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, 2012
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| Degree
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Pathology, Speciality
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50 p.: tab
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| Note
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This thesis is also a research project with project- ID 389447
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| Abstract
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Meningiomas account for 15-30 percent of alll primary intracranial tumors. They are divided into three grades, Recurrence is an issue following surgical treatment of meningioma. especially in grads II and III. HER2 is a transmembrane glycoprotein with tyrosine kinase activity and can be a potential target for therapeutic intervention with selective inhibitors. The aim of this study was to determine the relationship between meninigioma and HER2 Expression. Seventy- two paraffin blocks of meningioma were selected randomly, and immunohistochemical staining was then prformed for each specimen. P- value less than 0.05 was considered as significant. Thirty- One of the 72 meningiomas were HERS- positive. Her2 expression was observed in 11 ( 55 percent) of the 20 grade II/III, and 20 ( 38.5 Percent ) of the 52 grade I meningiomas. HER2 expression was detected in 43 Percent of meningiomas, No significant difference was seen between grade I and II / III meningiomas, primary and recurrent tumors, and males and females from the point of veiw of HER2 expression.
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| Descriptor
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1. Meningioma.- Descriptors: Immunohistochemistry
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Meningioma
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Brain Neoplasms
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Antibadies, Monoclonal
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Antibadies, Formation
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| Added Entry
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Mahzoni, Parvin, Supervisor
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