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" Association of urinary transforming growth factor-B1 with ureteropelvic junction obstruction "
/عماد بهرامینیا
; Alireza Merrikhi
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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102956
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| Doc. No
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T13674
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WJ,400,B151a,2012
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| Main Entry
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Bahraminia, Emad
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| Title & Author
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Association of urinary transforming growth factor-B1 with ureteropelvic junction obstruction/عماد بهرامینیا
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| College
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Schools, Medical
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| Date
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, 2012
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| Degree
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Pediatrics, Speciality
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| Page No
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14p.: dig, tab
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| Note
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This is a research dissertation with project ID: 390546
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| Note
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Orginal works
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| Abstract
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Abstract: Aims: We aimed to compare the level of urinary transforming growth factor-betal (TGF-(31) in children with ureteropelvic junction obstruction (UPJO) with the normal peers. Methods: In this case-control study, we enrolled children with UPJO and matched normal peers. Sterile urine was collected from the subjects and urinary TGF-131 was measured by ELISA method. Also, degree of the UPJO and the magnitude of the renal injury were assessed by ultrasonography and measuring glomerular filtration rate (GFR), respectively. Study variables were then compared between the study groups regarding the level of urinary TGF-f31. Results: A total of 25 children with UPJO (age= 7.4+4.5 years; male=16) were compared with 25 healthy peers (age= 6.8+5.6 years; male=16). Mean GFR in the UPJO and the control group were 112.4+10.1 and 123.29+4.4, respectively. Mean urinary TGF-01 in the UPJO group was 87.1+12.6 pg/ml versus 30.5+14.5 pg/ml in the control group. The level of urinary TGF-131 was significantly associated with the degree of TGF431 and patients with grade IV hydronephrosis had the highest level of urinary TGF-13 (p=0.0001). Conclusion: based on our findings, biomarkers such as TGF-131 can successfully be used for diagnosing UPJO. However, further studies are needed to determine the proper cut point for diagnosis..
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| Descriptor
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1. Ureteral Obstruction.- Descriptors: Ureteral Obstruction
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Ureteral Diseases
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Kidney, Pelvis
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Kidney Diseases
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Hematuria
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| Added Entry
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Merrikhi, Alireza, Supervisor
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| Translated Title Supplied by Cataloguer
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عنوان به فارسی: بررسی ارتباط شرح ادراری TGF_B1 و شدت بیماری انسداد محل اتصال لگنچه به حالب در کودکان مبتلای مراجعه کننده به درمانگاه نفرولوژی کودکان در بیمارستان الزهرا در سال۱۳۹۰
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