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" Variations in ESR and CRP in Total Knee Arthroplasty (TKA) and Total Hip Arthroplasty (THA) in Patients going to Isfahan's Educational Treatment Centers from 2009 to 2011 "
/mehdi yousefian
; Khalil Allah Nazem, Mehdi Motiffifar
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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102963
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| Doc. No
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T13632
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WE,860,Y82v,2012
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| Main Entry
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Yousefian, Mehdi
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| Title & Author
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Variations in ESR and CRP in Total Knee Arthroplasty (TKA) and Total Hip Arthroplasty (THA) in Patients going to Isfahan's Educational Treatment Centers from 2009 to 2011/mehdi yousefian
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| College
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Schools, Medical
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| Date
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, 2012
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| Degree
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Pediatrics, Speciality
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| Page No
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8p.: dig, tab
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| Note
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This is a research dissertation with project ID: 390101
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مهدی یوسفیان
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Orginal works
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| Abstract
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Background and Objective: Implantation of joint prosthesis, either in knee or in hip, may cause some problems like an infection, so that a timely treatment is essential.In this respect, discovering or inventing a marker detecting the incidence of an infection is one of the requirements of arthroplasty. One such marker is the variation in ESR (Erythrocyte Sedimentation Rate) and CRP(C-reactive protein).So far, numerous studies have been conducted in different parts of the world on ESR and CRP as markers of infection in patients, but have shown contradictory results. According to these different results, it seems that race and relevant factors such as level of public health and environmental factors affect the process. Therefore, the present study was conducted to determine variations in these two markers in arthroplasty and incidence of infection in patients. Materials and Methods: This prospective study was carried out in Isfahan's educational treatment centers from 2009 to 2011. The study population was patients undergoing TKA and THA surgical operations, with no history of inflammatory, infectious, and chronic diseases. The patients underwent ESR and CRP tests the day before operation, the day of operation, and 1, 2, 5, and 15 days and 1, 3, 6, and 12 months after operation and variations in these two markers were examined. Patients who suffered complications like prosthetic fracture or died were excluded from the study. The patients with abnormal process of ESR and CRP underwent bone scan and were followed up for 1 year in order to detect the incidence of infection and they were excluded from calculations. The data were analyzed using SPSS18 software. Results: Mean ESR had an upward trend during the first five days then decreased gradually. This reduction trend lasted to 3 months; however, after one year it increased to a level higher than that of before operation. Analysis by repeated measures ANOVA test showed that variations in ESR before the operation (19.1▒12.9) and one year after (21.14▒10.8) were significantly different (P<0.001). Level of CRP had an upward trend from the first day after operation and reached its maximum on the second day, then had a downward trend up to one month after the operation; however, it did not reach its preoperative level during 1 year.Mean CRP before operation and I year after operation was 4.07▒2.9 and 13.9▒9.6, respectively.The analysis of data by repeated measures ANOVA showed the variations in crp changed -significantly within 1 year (P<0.001). During the study, normalization process of ESR and CRP was abnormal in 4 (5 ) patients who underwent bone scan. The result of the bone scan of 2 patients was negative, however, the positive result in 2 other patients proved the presence of infection during the operation.Conclusion: There may be an infection when the level of CRP and ESR in patients undergoing TKA and THA operations exceeds normal limits..
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| Descriptor
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1. Arthroplasty.- Descriptors: Arthroplasty
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Arthroplasty, Replacement, Hip
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Arthroplasty, Replacement, Knee
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C- Reactive Protein
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Blood Sedimentation
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| Added Entry
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Nazem, Khalil Allah, Supervisor
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Motiffifar, Mehdi, Supervisor
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| Translated Title Supplied by Cataloguer
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عنوان به فارسی: بررسی روند تغییرات طبیعی ESR و CPR در اعمال جراحی مفصل زانو (TKA) و تعویض مفصل هیپ (THA) در بیماران مراجعه کننده به مراکز آموزشی درمانی شهر اصفهان طی سالهای ۸۸ و ۸۹ و ۱۳۹۰ و پیگیری بیماران و بررسی outcom آنها
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