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" The Mortality and response rate after flang rejimen in patients with refractory/relapsed acute leukemia "
/لیدا لیاقت
; Valiallah Mehrzad
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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102972
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| Doc. No
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T13618
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WH,380,L525m,2012
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| Main Entry
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Liaghat, Lida
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| Title & Author
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The Mortality and response rate after flang rejimen in patients with refractory/relapsed acute leukemia/لیدا لیاقت
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| College
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Schools, Medical
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| Date
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, 2012
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| Degree
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Medicine, M.D.
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| Page No
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6p.: diag, tab
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| Note
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This is a research dissertation with project ID: 389318
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| Note
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Orginal works
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| Abstract
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Oncologists today are greatly concerned about the treatment of relapseclirefractory aoace leukemia. FLAK regimen, combination of novantron, cytarabiner fludarabine, and granulocyte-colony stimulating factor, has been used in treatment of refractory/relapsed acute leukemia since 1990s. The present study has evaluated mortality and response rate of this regimen. Ma teriats and Methods! In this study, 25 patients with refraaoryfrelapsed acute leukemia aged 15-55 years underwent FLANG regimen at Seyed-Al-Shohada Hospital, isfahati, Iran during 2008-2009. One month later, bone marrow samples were taken co evaluate the responsiveness to treatment- Participants were followed for a year. The data was analyzed by student.t and chi-square tests, logistic, and COX regression analysis, and Kaplan-Meier curves in SPSS . Results; Out of the 25 patients, 8 patients ON had acute lymphoblas-dc leukemia 5 refractory and 3 relapsed casesi and 17 subjects had acute myeloid leulcem1447 refractory and 10 relapsed cases). According to the bone marrow biopsies taken one month after FLAN regimen. 10 patients (4016) had responded to treatment. Five patients of the 10 responders underwent successfOone marrow transplantation (ft MT), On the other hand. 13 patients i52 ), who had not enters qW CR period, died during the fo I low, up. Logistic regression analysis did not reveal any significant asso d:SMI s between disease type and responsiveness to treatment. Conclusion: This study indicated پ higher rates of unreponsiveness to treatment while its mortality rate was comparable with other studies. Overall, accordingco limitations for BIT (as the only chance for Cif ell in Iran, it seems that FLANC therapy is an:accept01e choice for these patients.
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| Descriptor
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1. Bone Marrow Transplantation.- Descriptors: Bone Marrow Transplantation
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Anemia, Refactory
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Lukemia
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| Added Entry
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Mehrzad, Valiallah, Supervisor
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