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" Heart rate and cardiovascular event: A nested case- control in Isfahan Cohort Study "
/ایمان زند
; Masoumeh Sadeghi
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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103063
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| Doc. No
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T13879
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| Call number
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WG,141,Z27h,2012
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| Main Entry
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Zand, Iman
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| Title & Author
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Heart rate and cardiovascular event: A nested case- control in Isfahan Cohort Study/ایمان زند
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| College
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Schools, Medical
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| Date
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, 2012
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| Degree
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Cardiology, Speciality
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| student score
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, , 1392/04/25
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13 p.: tab
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| Note
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This thesis is also a resesarch project with project ID:391050
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| Abstract
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Introduction: The aim of the present study was to investigate the association of elevated heart rate (HR) with the occurrence of cardiovascular disease (CVD) events in Iranian adults. Methods: Isfahan cohort study (ICS) was a longitudinal study started in 2001 among 6504 adults aged ?..35 years in urban and rural areas of central Iran. In a nested case control study, a control was randomly selected for each CVD event occurred during 7 years of follow up using density sampling method. HR at baseline was assessed by electrocardiogram. CVD was defined as incident coronary heart disease (myocardial infarction, unstable angina and sudden cardiac death) and stroke. The odds ratios (OR) were estimated by conditional logistic regression. Results: 432 participants with CVD events in the case group and 401 participants free of CVD in the control group were included in the analysis. While HR did not show any significant relationship with CVD events in crude model (P = 0.208), it was detrimentally associated with CVD when age was included (OR = 1.01, 95 CI 1.00-1.02, P = 0.024). Last quintile (> 84.9 bpm) of HR showed 65 age adjusted increased risk of CVD events (OR = 1.65, 95 CI 1.01-2.70, P = 0.045). Except for diabetes (OR = 1.63, 95 CI 0.972.73, P = 0.061), this association remained significant when other risk factors were included in the model. Conclusions: An elevated heart rate may be considered as a predictor of cardiovascular disease independently of other risk factors in Iranian adults..
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| Descriptor
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1. Cardiovascular Diseases.- Descriptors: Heart Rate
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Cardiovascular Disease- diagnosis
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Stroke
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| Added Entry
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Sadeghi, Masoumeh, Supervisor
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