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" A comparative study on the prophylactic effect of ketamine, dexamethasone and pethidine in preventing postoperative shivering "
/لیلا مروتی
; Morteza Heidari
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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103065
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| Doc. No
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T13883
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WO,184,M871c,2012
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| Main Entry
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Morovvati, Leyla
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| Title & Author
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A comparative study on the prophylactic effect of ketamine, dexamethasone and pethidine in preventing postoperative shivering/لیلا مروتی
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| College
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Schools, Medical
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| Date
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, 2012
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| Degree
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Anesthesiology, Speciality
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| student score
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, , 1392/04/25
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| Page No
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7P.: chart, tab
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| Note
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This thesis is also a resesarch project with project ID:389348
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| Abstract
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Postoperative shivering is one of the most common problems in the early recovery phase following general anesthesia. it is considered as the sixth most important problem of current clinical anesthesiology with an estimated rate of 5-65 . It not only makes distress in patients but also may result in different physiological changes including increased tissue Oxygen consumption and carbon dioxide production which consequently increase the cardiac output and minute ventilation. These stressful physiologic conditions may cause complications in the elderly and coronary artery disease patients. Postoperative shivering was first described over 50 years ago. Though initial evidences indicated that intrauperative hypothermia and reset of thermoregulatory centers are the main causative factors, its occurrence among normothermic patients has led scientists to seek other relative factors. Several studies have investigated the mechanisms responsible for postoperative shivering but the precise origin has not been clearly determined yet. A 'lumber of hypotheses have been developed in this regard and many pharmacological interventions have been investigated for management of this important postanesthetic complication. The use of some paarmacological agents such as clonidine, ketamine, doxapram, tramadol, pethidine, and other opioids has been studied in many researches. Among the mentioned agents, pethidine is one of the most effective drugs in treatment and prevention of postanesthetic shivering. It has been suggested that pethidine could directly affect the thermoregulatory center or may act through upioid receptors. However, its underlying mechanisms have not been understood to date. As mentioned, different hypotheses have been recommended regarding the role of thermoregulatory and non-therrnoregulatory reactions. N-methyl-Daspartate (NMDA) receptor antagonists are among the thermoregulatury factors which might modulate thermoregulation at multiple levels. Therefore, ketamine, as a competitive NMDA receptor antagonist, could be effective for this purpose..
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| Descriptor
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1. Postoperative Complications- drug therapy.- Descriptors: Postoperative Complications- drug therapy
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Ketamine
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Dexamethasone
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Meperidine
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Shivering
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| Added Entry
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Heidari, Morteza, Supervisor
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| Translated Title Supplied by Cataloguer
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بررسی مقایسهای اثرات پروفیلاکسی تزریق وریدی داروهای دگزامتازون، کتامین و پتیدین بر روی لرز پس از عمل جراحی
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