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" Investigation of the relationship between MDM2 expression and tumor thickness and invasion in primary cutaneos malignant melanoma "
/پریدخت کریمیان
; Parvin Rajabi, Mitra Heidarpour
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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103066
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| Doc. No
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T13880
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| Call number
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QZ,200,K18i,2012
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| Main Entry
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Karimian, Paridokht
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| Title & Author
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Investigation of the relationship between MDM2 expression and tumor thickness and invasion in primary cutaneos malignant melanoma/پریدخت کریمیان
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| College
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Schools, Medical
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| Date
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, 2012
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| Degree
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Pathology, Speciality
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| Page No
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[4] p.: tab
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| Note
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This thesis is also a resesarch project with project ID:389056
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| Abstract
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The incidence of melanoma has continued to increase worldwide. Incidence rates vary with respect to age and gender. While melanoma is more common in women than in men prior to 50 years of age, this trend reverses after age 50.11 5) Although melanoma accounts for roughly 4 of all skin cancers, it is responsible for more than 74 of skin cancer deatbs. Tumor thickness, as defined by the Breslow index, is the most important histological prognostic factor of melanoma and is measured vertically in millimeters from the top of the granular layer (or base of superficial ulceration) to the deepest point of tumoral involvement. Increased tumor thickness suggests a higher metastatic potential and a poorer prognosis. The Clark level on the other hand, is a measure of the anatomical invasion of the tumor and appears to affect prognosis only in thinner (<1 mm of depth) melanomas. Murine double minute 2 (MDM2) is a 491 amino acid protein that functions as a key regulator of P53by binding to its N-terminus, inhibiting its transcriptional activity, and promoting its degradation. MDM2 overexpression or hyperactivation directly contributes to loss of p53 function during the development of nearly 50 of human cancers. Amplification of the genetic locus of MDM2 is a common event in several tumors including glioma, liposarcoma, osteosarcoma, pancreatic ductal adenocarcinoma, and germ cell tumors. The MDM2 immunoreactivity of tumoral cells has also been shown to be potentially correlated with the outcorneitmot A strong correlation between MDM2 expression and progressive disease has also been demonstrated.Most previous studies have used polymerase chain reaction (PCR) for their analyses. However, we used immunohistochemical techniques because finding a significant correlation between MDM2 expression and tumor thickness and invasion would introduce a predictive prognostic marker for cutaneous malignant melanoma. Therefore, the relationship between MDM2 expression and tumor thickness and invasion in primary cutaneous malignant melanoma was evaluated..
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| Descriptor
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1. Melanoma.- Descriptors: Melanoma
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Proto-Oncogene Proteins c-mdm2
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| Added Entry
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Rajabi, Parvin, Supervisor
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Heidarpour, Mitra, Supervisor
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