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" Memantine add on to Citalopram in Elderly Patients with Depression: A Double-blind Placebo-Controlled Study "
/الهام شیرزادی
; Victoria Omranifard, Hamid Afshar
; Saeid Samandari
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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103316
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| Doc. No
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T14645
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| Call number
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WM,171.5,S558m,2014
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| Main Entry
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Shirzadi, Elham
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| Title & Author
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Memantine add on to Citalopram in Elderly Patients with Depression: A Double-blind Placebo-Controlled Study/الهام شیرزادی
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| College
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Schools, Medical
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| Date
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, 2014
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| Degree
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Psychiatry, Speciality
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| Page No
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21 p.: tab
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| Note
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This is a research dissertation with project ID: 390231
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| Abstract
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Proper management of depression in elderly population would improve the outcome of the disease and reduce its related disability and mortality. Use of memantine with minimal side effects and drug interaction seems reasonable in elderly but its antidepressant activity is controversial. The aim of current research was to investigate the effect of add on memantine on Citalopram therapy in elderly patients with depression in Isfahan. In this double-blind, placebo controlled trial study; newly diagnosed depressive elderly patients aged > 60 years were enrolled. Selected patients were randomized in two intervention and placebo groups. The intervention was memantine (20 mg daily) or identical placebo plus Citalopram for 8 weeks. Severity of depression and quality of life was evaluated using Geriatric Depression Scale (GDS-15) Hamilton Rating Scale for depression (HRSD) and WHO-QOL-(brief) respectively. Mentioned scores evaluate at baseline and 4 weeks and 8 weeks, after initiating trial in two studied groups and compared with each other. 28 and 29 patients were studied in intervention and placebo groups, respectively. Score of GDS-15 ( Geriatric depression scale ), HDRS (Hamilton depression rating scale) and WHO-QOL (Quality of life)- (brief) scales at baseline, 4 weeks and 8 weeks, after initiating trial did not changed significantly after memantine use ( P>0.05 ). There was not significant difference in Mean +/- SD of GDS-15,HRSD and WHO- QOL-(brief) scales among intervention and placebo groups ( P>0.05 ). The outcome of this clinical trial did not support the antidepressant effect of add-on memantine in elderly patients with depression receiving citalopram. It is recommended to design further studies considering mentioned limitations of current study and the effect on memantine with other anti-depressant agents.
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| Descriptor
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1. Depression.- Descriptors: Depression
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Antidepressive Agents
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Memantine
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Citalopram
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Quality of Life
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| Added Entry
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Omranifard, Victoria, Supervisor
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Afshar, Hamid, Supervisor
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Samandari, Saeid, Advisor
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| Translated Title Supplied by Cataloguer
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بررسی تاثیر افزودن ممانتی به سیتوپرام بر علائم افسردگی و کیفیت زندگی سالمندان مبتلا به اختلال افسردگی اساسی در مقایسه با دارونما در سال۹۰
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