|
" Effects of adjunct vitamin D on retinal nerve fiber layer in vitamin D deficient patients with optic neuritis: preliminary findings of a randomized, placebo-controlled trial "
/مهری سالاری
; Masoud Etemadifar, Hasan Razmjoo
| center
|
:
|
Isfahan University of Medical Sciences
|
| Document Type
|
:
|
Latin Dissertation
|
| Language of Document
|
:
|
English
|
| Record Number
|
:
|
103336
|
| Doc. No
|
:
|
T14704
|
| Call number
|
:
|
WW,280,S161e,2014
|
| Main Entry
|
:
|
Salari, Mehri
|
| Title & Author
|
:
|
Effects of adjunct vitamin D on retinal nerve fiber layer in vitamin D deficient patients with optic neuritis: preliminary findings of a randomized, placebo-controlled trial/مهری سالاری
|
| College
|
:
|
Schools, Medical
|
| Date
|
:
|
, 2014
|
| Degree
|
:
|
Neurology, Speciality
|
| Page No
|
:
|
22 p.: Tab, diag.
|
| Note
|
:
|
This is a research dissertation with project ID: 290090
|
| Abstract
|
:
|
To evaluate the effect of oral vitamin D on the thickness of retinal nerve fiber layer (RNFL) in vitamin D deficient patients with optic neuritis (ON) by optical coherence tomography (OCT). A phase II placebo-controlled randomized clinical trial conducted between July 2011 and November 2012 included 52 patients with confirmed unilateral On aged 15 to 38 years and low serum 25- hydroxyvitamin D levels. the main outcome measures were changes in thickness of RNFL and macula 6-months of treatment with either 50000 IU/week vitamin D or placebo. In the 27 patients treated with vitamin D, the mean (SD) thickness of RNFL decreased from 111.3 (18.9) um at baseline to 91.4 (13.3) at the end of study period. correspondingly, in the 25 25 patients treate with placebo, the mean (SD) thickness of RNFL decreased from 113.7 (21.5) um at baseline to 96.1 (12.3) at the end of study period. in both groups, the mean thickness of the macula did not changed. average thickness of RNFL at the end of trial did not differ between groups. adding vitamin D to routine disease therapy had no significant effect on the thickness of RNFL or macula in patients with ON.
|
| Descriptor
|
:
|
1.Optic Neuritis.- Descriptors: Optic Neuritis
|
|
|
:
|
Retinaldehyde
|
|
|
:
|
Vitamin D
|
| Added Entry
|
:
|
Etemadifar, Masoud, Su[ervisor
|
|
|
:
|
Razmjoo, Hasan, Supervisor
|
| Translated Title Supplied by Cataloguer
|
:
|
بررسی تاثیر ویتامین D بر تغییرات رتین در بیماران مبتلا به نوریت اپتیک با استفاده از روش OCT
|
| |