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" Ameliorative effect of melatonin against contrast media induced renal tubular cell injury "
/مریم توکلی
; Hamid Nasri
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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103338
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| Doc. No
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T14703
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| Call number
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WN,150,T231a,2014
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| Main Entry
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Tavakoli, Maryam
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| Title & Author
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Ameliorative effect of melatonin against contrast media induced renal tubular cell injury/مریم توکلی
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| College
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Schools, Medical
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| Date
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, 2014
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| Degree
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Internal medicine, Specialty
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[5] p.: tab.
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| Note
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This is a research dissertation with project ID: 14703
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| Note
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Orginal works
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| Abstract
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Reactive oxygen species (ROS) is a mediator of renal damage. melatonin is a potent-free radical scavenger. our objective was to test whether melatonin would protect against the nephrotoxicity of contrast media. in an experimental study 40 adult male wistar rats were randomly divided into four equal groups includings: 1) control group (no drug), 2) contrast media group (10 ml/kg iodixanol i.v. single dose), 3) contrast media and melatonin (first 10 ml/kg iodixanol then 10 ml/kg melatonin by i.p. injectionon days 3, 4 and 5) contrast media and melatonin pretreatment group (melatonin 10 ml/kg/ day by i.p. injection on 1, 2 and 3 days, then 10 ml/kg iodixanol by i.v. injection on third day. the blood creatinine and BUN as well as the histological changes were evaluated for severity of renal injury (degeneration, vacuolization of tubular renal cells, dilatation of tubular lumen and presence of debris in the lumens), by scoring from one to four. contrast media significantly increased the creatinine and BUN and renal injury. melatonin prevented and reversed the injury induced by contrast m3eiq. pretreatment with melatonin reduced the renal injury induced by contrast media. melatonin is an effective drug to prevent contrast-induced renal injury. therefore its usage (especially pretreatment) might be beneficial in patients who are planning to use contrast media agents.
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| Descriptor
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1. Contrast Media.- Descriptors: Contrast Media
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Melatonin
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Reactive Oxygen Species
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Renal Insufficiency
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iodixanol
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| Added Entry
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Nasri, Hamid, Supervisor
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| Translated Title Supplied by Cataloguer
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بررسی اثر ملاتونین در پیشگیری از نفروتوکسیسیتی حاد ناشی از کنتراست مدیا
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