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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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103345
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| Doc. No
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T14899
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| Call number
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WK,270,A512d,2013
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| Main Entry
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Ameri, Farahnaz
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| Title & Author
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Diagnostic value of CD-10 marker in Differentiating Papillary Thyroid Carcinoma from Benign Thyroid Lesions/فرحناز عامری
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| College
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Schools, Medical
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| Date
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, 2013
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| Degree
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Pathology, Speciality
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| Page No
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16 p.
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| Note
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This is a research dissertation with project ID: 390201
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| Note
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Orginal works
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| Abstract
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Using of CD10 in accordance with clinical and histological features of thyroid lesions could be used as both diagnostic and prognostic tool which consequently influence the management and their prognosis for survival of patients with thyroid neoplasms specially papillary thyroid carcinoma (PTC). The aim of this study was to determine its expression in PTC and different benign thyroid lesions. Materials and Methods: In this descriptive-analytic, cross sectional study, paraffin-embedded tissues of patients with definitive pathologic diagnosis of different benign thyroid lesions and PTC were retrieved. Immunostained sections of each slides was performed using Immunohistochemistry methods and expression of CD10 was compared in two groups of benign thyroid lesions and PTC. Results: From selected cases 134 sections studied in two groups of Papillary thyroid carcinoma (n=67) and benign thyroid lesions (n=67). CD10 were immunohistochemically positive in 29.9 percent of PTC cases, but in none of the thyroid benign lesions (0 percent)(P<0.001). There was not significant relationship between expression of CD10 with age and sex of studied population (P>0.05). Conclusion: The results of current study indicate that due to the higher expression of CD10 in PTC than benign thyroid lesions it might be used for differentiating mentioned lesions. But for using it as diagnostic tool further studies with larger sample size and determination of its sensitivity, specificity and cutoff point is necessary.
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| Descriptor
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1.Thyroid Neoplasms.- Descriptors: Thyroid Neoplasms
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Carcinoma, Papillary
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Antigens, Differentiation
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Immunohistochemistry
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| Added Entry
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Mokhtari, Mojgan, Supervisor
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http://elib.mui.ac.ir/site/catalogue/103345
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