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" Pistacia Atlantica resin has a dose-dependent effect on angiogenesis and skin burn wound healing in rat "
/فریدون حقدوست
; Shaghayegh Haghjoo Javanmard
; Behzad Zolfaghari
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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103346
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| Doc. No
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T14898
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| Call number
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WO,185,H145p,2013
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| Main Entry
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Haghdoost, Faraidoon
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| Title & Author
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Pistacia Atlantica resin has a dose-dependent effect on angiogenesis and skin burn wound healing in rat/فریدون حقدوست
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| College
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Schools, Medical
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| Date
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, 2014
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| Degree
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Medicine, MD
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| Page No
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8 p.: ill., tab
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| Note
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This is a research dissertation with project ID: 289065
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| Note
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Orginal Works
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| Abstract
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The aim of the present study was to evaluate the effect of Pistacia atlantica resin extract on the rat skin burn wound healing. Thirty two Wistar rats were divided into four groups and treated by vehicle, 5 percent, 10 percent and 20 percent concentration of Pistacia atlantica resin extract for 14 days (G1, G2, G3 and G4 respectively). The efficacy of treatment was assessed based on reduction of burn wound size, histological and molecular characteristics. a-pinene (46.57 percent) was the main content of essential oil of resin. There were no statistically significant differences between groups according to wound size analysis. The mean histological wound healing scores were not statistically different. Capillary counts of G2 and G3 were significantly higher than the G1 (P=0.042 and 0.032, respectively). NO concentration in wound fluids in the 5th day of study was not significantly different between groups (p=0.468). But bFGF concentration in G2 and G3 and PDGF concentration in G3 were significantly higher in comparison to G1 (P=0.043, 0.017 and 0.019, respectively). Our results revealed that Pistacia atlantica resin extract has a concentration-dependent effect on the healing of burn wounds after 14 days treatment by increasing the concentration of bFGF and PDGF and also through improving the angiogenesis.
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| Descriptor
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1. Wound Healing.- Descriptors: Wound Healing
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Pistacia
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Plants, Medicinal
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Burns
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Angiogenesis Inhibitors
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| Added Entry
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Haghjooy Javanmard, Shaghayegh, Supervisor
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Zolfaghari, Behzad, Advisor
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