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" The Association of Body Mass Index with Disease Activity and Clinical Response to Combination Therapy in Patients with Rheumatoid Arthritis "
/مریم میرپوریان
; Mansour Salehi
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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103350
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| Doc. No
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T14894
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WE,346,M676a,2013
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| Main Entry
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Mirpourian, Maryam
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| Title & Author
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The Association of Body Mass Index with Disease Activity and Clinical Response to Combination Therapy in Patients with Rheumatoid Arthritis/مریم میرپوریان
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| College
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Schools, Medical
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| Date
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, 2013
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| Degree
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Internal Medicine ( Romathology ), Speciality
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| Page No
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24 p.: tab
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| Note
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This thesis is a research project with project ID 390387
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| Note
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Orginal Works
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| Abstract
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The role of obesity in clinical curse of rheumatoid arthritis (RA) is not clear. We investigated the association of obesity/adiposity with disease activity and clinical response to combination therapy in RA patients. Active RA patients with Disease Activity Score using 28 joint counts (DAS28) > 2.6 were studied. Height, weight, and waist and hip circumferences were measured and body mass index (BMI) and waist/hip ratio were calculated. Patients were treated with methotrexate (7.5 to 10 mg/week) plus hydroxychloroquine (200 to 400 mg/day) and prednisolone (2.5 to 10 mg/day) and were followed by DAS28 for up to 24 weeks. One hundred and six patients were studied; age = 48.5 +- 13.8 years, 87.7 percent female, disease duration = 4.4 years [SE = 0.48]. DAS28 was decreased from 4.5 +- 1.6 to 2.9+- 1.4 (P < 0.001) after 24 weeks of treatment. Only in patients with disease duration of < and = 2 years, BMI (r = -0.415, P = 0.005) and waist circumference (r = -0.296, P = 0.05) were correlated with baseline DAS28. Although BMI (r = -0.337, P = 0.025) and waist circumference (r = -0.315, P = 0.038) were correlated with change in DAS28 after therapy, these correlations were disappeared after controlling for baseline DAS28. Obesity and adiposity are associated with less severe disease activity in early stage of RA, but are not associated with response to combination therapy with methotrexate plus hydroxychloroquine in RA patients.
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| Descriptor
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1.Arthritis, Rheumatoid.- Descriptors: Arthritis, Rheumatoid
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Body Mass Index
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Drug Therapy, Combination
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Methotrexate
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| Added Entry
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Salehi, Mansour, Supervisor
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| Translated Title Supplied by Cataloguer
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بررسی ارتباط BMI با پاسخ به درمان در بیماران روماتیسم مفصلی
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