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" The efficacy of N.Acetylcysteine in the treatment of methamphetamine dependence: A double-blind controlled, cross-over study "
/محمدرضا شعرباف چی زاده
; Ghafour Mousavi
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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103362
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| Doc. No
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T14950
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WM,275,S531e,2014
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| Main Entry
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Sharbafchi, Mohammad Reza
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| Title & Author
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The efficacy of N.Acetylcysteine in the treatment of methamphetamine dependence: A double-blind controlled, cross-over study/محمدرضا شعرباف چی زاده
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| College
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Schools, Medical
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| Date
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, 2014
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| Degree
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Psychiatry, Speciality
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21 p.: tab
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| Note
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This thesis is a research project with project ID: 391070
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| Abstract
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Preclinical studies and early pilot clinical investigations have suggested that N-acetylcysteine (NAC) may be useful in treatment of methamphetamine (METH) dependence. The present study evaluated whether NAC would suppress craving to the METH. In a double-blind, controlled cross-over clinical trial, 32 METH-dependent volunteers were chose to receive either NAC (1200 mg/day) or placebo, randomly. They were intervened in two four weeks sessions. During first session they received either 1200 mg/day of NAC (group A) or placebo (group B). After a three days of wash-out period, next session started with the cross-over intervention of the previous regimen. During this eight weeks, all participants received standardized, Matrix Model of treatment. Craving was assessed using the Cocaine Craving Questionnaire-Brief (CCQ-Brief). The data were analyzed using SPSS version 20.0 (SPSS Inc., Chicago, Illinois, USA). In 23 subjects who completed the study, the mean score of CCQ-Brief reduced in four consecutive weeks with NAC treatment. The mean (SD) scores of carving for group A and B were 3.38 (1.16) and 5.96 (1.03), at the end of first session; and 4.57 (1.88) and 3.2 (0.86), at the end of second session, respectively. Our findings indicate that the main effect was significant for NAC (P < 0.001). Across placebo and NAC conditions, only mild side effects were noted, and the number of subjects who reporting side effects did not differ. The NAC showed good efficacy in suppressing METH craving, and may be a useful pharmacological treatment for METH dependence.
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| Descriptor
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1. Methamphetamine.- Descriptors: Methamphetamine
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Dependency (Psychology)
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Craving
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Acetylcysteine
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Drug Therapy
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| Added Entry
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Mousavi, Ghafour, Supervisor
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| Translated Title Supplied by Cataloguer
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بررسی مقایسه ای ان استیل سیستئین (NAC) با دارونما در کاهش اشتیاق به مصرف در مبتلایان وابستگی به مت امفتامین
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