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" Evaluation of endothelial function in exogenous subclinical hyperthyroidism and the effect of treatment "
/Mohammad Hosseini
; Noushin Khalili, Ashraf Aminorroaya
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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103364
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| Doc. No
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T14948
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WK,265,H825e,2014
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| Main Entry
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Hoseini, Mohammad
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| Title & Author
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Evaluation of endothelial function in exogenous subclinical hyperthyroidism and the effect of treatment/Mohammad Hosseini
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| College
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Schools, Medical
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| Date
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, 2014
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| Degree
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Internal Medicine, Speciality
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17 p.: tab
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| Note
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This thesis is a research project with project ID: 393028
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| Abstract
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Subclinical hyperthyroidism is a widespread condition in which cardiovascular manifestations are frequently occur but there is still a debate about the vascular responsiveness in it. Measuring FMD and IMT are used to evaluate endothelial function in these patients. Twenty five patients with diagnosis of exogenous subclinical hyperthyroidism and 25 full matched healthy subjects were enrolled. At first FMD of brachial artery and IMT of common carotid artery were obtained from all the participants. In the second phase, for subclinical hyperthyroidism patients levothyroxin dosage decreased 25 of prior used dosage every 2 months till TSH become normal. Measuring FMD and IMT was repeated after this intervention in case group. The mean age of case and control groups was 38.48+/-12.05 and 36.72+/- 11.15 years respectively. The mean of FMD in healthy people was dramatically higher than the subclinical hyperthyroid patients (P<0.001) but no statistically significant difference was found for IMT (P=0.459). After intervention in case group FMD was meaningfully increased (P<0.001) but IMT of common carotid artery was not considerably changed (P=0.491). This study demonstrated that FMD decreased in exagenous sub clinical hyperthyroid patients which could be partially restored by treatment. These findings suggest that treatment of subclinical hyperthyroid state could improve endothelial dysfunction and at the end decreased the cardiovascular complications.
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| Descriptor
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1. Hyperthyroidism.- Descriptors: Hyperthyroidism
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Endothelium
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| Added Entry
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Khalili, Noushin, Supervisor
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Aminorroaya, Ashraf, Supervisor
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| Translated Title Supplied by Cataloguer
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بررسی عملکرد اندوتلیوم در بیماران مبتلا به پرکاری تیروئید تحت بالینی اگزوژن قبل و بعد از یوتیروئید شدن بیمار
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