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" Pruritus-reducing effects of omega-3 fatty acids in hemodialysis patients "
/مسعود مقتدری
; Mojgan Mortazavi
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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103371
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| Doc. No
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T14941
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| Call number
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WJ,378,M696p,2014
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| Main Entry
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Moghtaderi, Masoud
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| Title & Author
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Pruritus-reducing effects of omega-3 fatty acids in hemodialysis patients/مسعود مقتدری
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| College
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Schools, Medical
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| Date
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, 2014
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| Degree
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Internal Medicine, Specialty
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| Page No
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19 p.: tab
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| Note
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This thesis is a research project with project ID: 392301
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| Abstract
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Patients with end-stage renal disease (ESRD) suffer from many complaints, from which uremic pruritus is a common situation. In this report, we have explored the outcome of omega-3 supplementary intake for treatment of this bothering symptom. This double-blind, crossover study was carried out in two dialysis centers in which 40 hemodialysis patients suffering from pruritus were randomly assigned to two groups of omega-3-placebo (group A) and placebo-omega-3 (group B). Patients in group A, consumed fish oil capsules ( 1 gram capsules three times a day) for 4 weeks and after a washout period, they took placebo for another 4 weeks. The same was performed in group B, but in the reverse order. Pruritus score and serum levels of prostaglandin E2 was recorded at the beginning and end of each treatment period. There was a statistically significant reduction of pruritus score in patients who took omega-3 fatty acid supplement. The mean pruritus score was reduced by 1.72 in patients who took fish oil, compared to a decrease of 0.45 in the placebo group (p value = 0.03); but the changes in serum level of prostaglandin E2 was not statistically significant in either of the groups(P-values>0.05). No significant side effects of omeg-3 consumption were observed. This report contributes to the ongoing research for finding a promising treatment for uremic pruritus and our observations indicate that Omega-3 fatty acids (3 gram per day) have decreasing effects on this symptom. Also, there was no correlation between the level of prostaglandin E2 and the severity of pruritus in hemodialysis patients.
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| Descriptor
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1. Renal Dialysis.- Descriptors: Renal Dialysis
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Fatty Acids, Omega-3
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Dinoprostone
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Pruritus
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Uremia
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| Added Entry
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Mortazavi, Mojgan, Supervisor
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| Translated Title Supplied by Cataloguer
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بررسی اثر omega-3 بر شدت خارش بیماران تحت همودیالیز مداوم
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