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" Comparison between theophyllin and N-acetylcysteineand their combination for the prevention of contrast-induced nephropathy "
/مرتضی عرب مومنی
; Morteza Abdar Isfahani, Jamshid Najafian
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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103375
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| Doc. No
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T14937
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WJ,342,A658c,2014
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| Main Entry
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Arabmomeni, Morteza
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| Title & Author
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Comparison between theophyllin and N-acetylcysteineand their combination for the prevention of contrast-induced nephropathy/مرتضی عرب مومنی
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| College
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Schools, Medical
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| Date
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, 2014
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| Degree
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Cardiology, Specialty
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18 p.: tab
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| Note
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This thesis is a research project with project ID: 392300
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| Abstract
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Few studies compared the efficacy of theophylline with N-acetylcysteine or evaluated the efficacy of combination therapy in the prevention of contrast-induced nephropathy (CIN). We compared the efficacy of theophylline, N-acetylcysteine, and combination of these agents in the prevention of CIN.This randomized controlled trial was conducted on 96 patients referring consecutively to the Shahid Chamran University Hospital in Isfahan, Iran for elective coronary angiography (with our without angioplasty). Patients with at least moderate risk for CIN were included and were randomized to receive theophylline (200 mg), N-acetylcysteine (600 mg), or theophylline+N-acetylcysteine, twice daily, from 24 hours before to 48 hours after administration of the contrast material. A non-ionic contrast material with low contrast osmolality was used. Serum creatinine was measured before and 48 hours after contrast material injection. Serum creatinine was increased by 6.83+/-15.32 with theophylline, 13.09+/-14.63 with N-acetylcysteine, and 5.45+/-13.96 with theophylline+N-acetylcysteine after contrast material injection. Controlling for Mehran risk score, baseline serum creatinine concentration, and contrast volume used, the change in serum creatinine level was lower with theophylline compared with N-acetylcysteine (F=4.79, P=0.033), and with theophylline+N-acetylcysteine compared with N-acetylcysteine (F=5.78, P=0.020). CIN (increase in creatinine of >=0.5 mg/dL or >=25 from the baseline) was occurred in 20 , 21.9 , and 7.1 of patients in the theophylline, N-acetylcysteine, and theophylline+N-acetylcysteine groups, respectively (P=0.260). Theophylline is superior to N-acetylcysteine in preventing contrast-induced renal dysfunction. The combination of theophylline and N-acetylcysteine is superior to N-acetylcysteine alone, but not theophylline alone in this regard. Further trials with larger sample of patients are warranted (clinicaltrials.gov: NCT02088502).
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| Descriptor
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1. Acute Kidney Injury.- Descriptors: Acute Kidney Injury
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Theophylline
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Acetylcysteine
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Coronary Angiography
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Contrast Media
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| Added Entry
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Abdar Isfahani, Morteza, Supervisor
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Najafian, Jamshid, Supervisor
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| Translated Title Supplied by Cataloguer
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بررسی اثر مقایسه ای تئوفیلین، -N استیل سیستئین و تئوفیلین + -N استیل سیستئین در پیشگیری از نفروپاتی ناشی از کنتراست در بیماران با ریسک متوسط به بالا
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