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" Effect of metformin on TSH and thyroid volume in patients with pre-diabetes: a randomized placebo-controlled clinical trial "
/مژگان کریمی فر
; Ashraf Aminorroaya
; Bijan Iraj
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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103379
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| Doc. No
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T14933
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| Call number
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WK,810,K18e,2014
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| Main Entry
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Karimifar, Mozhgan
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| Title & Author
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Effect of metformin on TSH and thyroid volume in patients with pre-diabetes: a randomized placebo-controlled clinical trial/مژگان کریمی فر
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| College
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Schools, Medical
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| Date
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, 2014
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| Degree
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endocrinology, Speciality
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| Page No
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31 p.: tab
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| Note
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This thesis is a research project with project ID: 392299
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| Abstract
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The people with pre-diabetes have insulin resistance. Insulin resistance may affect thyroid function, size and nodules. We investigated the effects of metformin on the thyroid gland in pre-diabetic people. In a randomized double blind placebo-control clinical trial, 89 people with pre-diabetes, aged 18-65 years were studied for 3 months. They were divided into two, metformin (n= 43) and placebo (n = 46) treated groups. Serum TSH was measured and thyroid nodules and volume were studied by ultrasonography. The data were compared between and within groups, before and after the study. Mean of the baseline characteristics in metformin and placebo-treated groups had no statistically significant difference. At the end of the study, serum TSH was not significantly different between the two groups. However, if the TSH range was divided into two low normal (0.3 -2.5 إU/ml) and high normal (2.6 - 5.5 إU/ml) ranges, significant decrease was observed in metformin-treated group with a high-normal basal serum TSH (P=0.01). Thyroid volume did not change in metformin-treated group. However, in placebo-treated group, the thyroid was enlarged (P=0.03). In 53.9 of participants, thyroid nodule was observed. There was just a decrease in the volume of small solid (not mixed) nodules from median of 0.07ml to 0.04ml in metformin-treated group (P=0.01). In prediabetic people, metformin decreases serum TSH, only, in those people with TSH >2.5إU/ml and reduces the size of small solid thyroid nodules. It also prevents the increase in the thyroid volume.
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| Descriptor
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1. Prediabetic State.- Descriptors: Prediabetic State
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Insulin Resistance
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Thyroid Nodule
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Metformin
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| Added Entry
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Aminorroaya, Ashraf, Supervisor
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Iraj, Bijan, Advisor
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| Translated Title Supplied by Cataloguer
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تاثیر مت فورمین بر تیروئید در بیماران پره دیابت
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