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" The relationship between regional brain volumes and the extent of coronary artery disease in Mild cognitive impairment "
/ Hedyeh Askarpour
; Majid Barekatain
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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103389
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| Doc. No
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T14924
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WM,204,A834r,2014
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| Main Entry
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Askarpour , Hedyeh
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| Title & Author
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The relationship between regional brain volumes and the extent of coronary artery disease in Mild cognitive impairment/ Hedyeh Askarpour
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| College
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Schools, Medical
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| Date
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, 2014
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| Degree
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Psychiatry, Speciality
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| Page No
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24 p.: tab
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| Note
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This thesis is a research project with project ID: 391052
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| Abstract
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There are conflicting reports regarding the association between Coronary Artery Disease (CAD) and Mild Cognitive Impairment (MCI). Volumetric MRI investigations have been considered as an objective biomarker for MCI. In this paper we have looked at the relationship between the brain volumes of regions of interest and the extent of coronary artery disease in MCI and cognitively normal controls. In a cross-section, case-control study a subset of MCI patients (n=20) and cognitively normal controls (n=20), aged 66.4+/-4.6 and 65.3+/-3.9 respectively, from subjects who were recently admitted to cardiac catheterization facilities in 2 general hospitals were examined. All subjects underwent a clinical interview, biochemical measures, neuropsychological testing and Neuropsychiatry Unit Cognitive assessment tool (NUCOG). Video records of coronary angiography were scored with the Gensini method. For volumetric evaluation of regions of interest, brain MRI scans was processed using the FreeSurfer software package. We have found that, there were significant differences between the 2 groups in volumes of left fusiform (p=0.039), left pars triangularis (p=0.003) and left superior temporal gyrus (p=0.009), after controlling for intracranial volumes. Higher Gensini scores were associated with reduced volumes of total cortical volume (P=0.047, R= -0.4), left precuneus (P=0.022, R= -0.5), right inferior parietal lobule (P=0.011, R= -0.5) and left supra marginal gyrus (P=0.035, R=-0.04) in MCI.In MCI, a greater degree of coronary stenosis correlates with greater loss of gray matter in specific brain regions relevant to cognitive function. This, however, was not the case for cognitively normal subjects. Future longitudinal studies should aim at elucidation of the progressive nature and the biological link of CAD to decrease cerebral volumes and the cognitive impairment in MC.
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| Descriptor
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1. Mild Cognitive Impairment.- Descriptors: Mild Cognitive Impairment
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Magnetic Resonance Imaging
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Coronary Artery Disease
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| Added Entry
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Barekatain , Majid, Thesis advisor
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| Translated Title Supplied by Cataloguer
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بررسی شاخص های (MRI) مغزی و آنژیوگرافی قلبی در مبتلایان به اختلال شناختی خفیف (MCI) و مقایسه با گروه کنترل
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