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" An observational study on the expression of cyclooxygenase-2 in meningioma and its correlation with tumor grade "
/طناز سرمدی
; Parvin Mahzouni
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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103393
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| Doc. No
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T14969
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QZ,380,S246o,2014
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| Main Entry
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Sarmadi, Tannaz
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| Title & Author
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An observational study on the expression of cyclooxygenase-2 in meningioma and its correlation with tumor grade/طناز سرمدی
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| College
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Schools, Medical
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| Date
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, 2014
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| Degree
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Pathology, Speciality
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16 p.: tab
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| Note
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This thesis is a research project with project ID: 391338
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| Abstract
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the Cyclooxygemase-2 enzyme is overexpressed in different types of tumors and is known to be associated with malignant behaviour of tumors. we determined the asociation of COX-2 expression and different grades of human meningioma. this retrospective study was conducted on specimens obtained from adult patients with meningioma. meningioma was classified according to the WHO 2007 classification protocol (I, II, and III). COX-2 expression intensity was secored based on the percentage of immunopositive cells and 0:0-10 percent+1>10 percent and a part of the cell membrance; +2:.10percent and complete cell membrance; and +3:.30 percent and complete cell membrance. scores of +2 or +3 were considered as COX-2 positive. ninety meningioma cases were studied. COX-2 was positive in 25 percent (17/68), 68.4 percent (13/19) and 100 percent (3/3) of cases with tumor grade I, II and III, resectively. there was a significant correlation between tumor grade and COX-2 exression score. there is a strong association between COX-2 expression and rumoral grade in meningioma with more aggressive tumors expressing COX-2 expression with tumor recurrence and interventional studies examining the role of COX-2 inhibitors anticancer therapy of meningioma are warrated.
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| Descriptor
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1. Meningioma.- Descriptors: Meningioma
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Central Nervous System Neoplasms
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Meningioma
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| Added Entry
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Mahzouni, parvin, Supervisor
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| Translated Title Supplied by Cataloguer
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بررسی شیوع بیان مارکر COX-II در مننژیوما و ارتباط آن با گریدر عود تومور
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