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" Prevalence of Non- Alchoholic Fatty liver Disease and its related metabolic risk factors in Isfahan-Iran "
/شهاب مالکی
; Atoosa Adibi, Peyman Adibi
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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103394
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| Doc. No
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T14995
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| Call number
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WI,700,M245p,2014
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| Main Entry
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Maleki, Shahab
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| Title & Author
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Prevalence of Non- Alchoholic Fatty liver Disease and its related metabolic risk factors in Isfahan-Iran/شهاب مالکی
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| College
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Schools, Medical
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| Date
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, 2014
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| Degree
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Radiology, Speciality
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[No Paging]: diag., tab
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| Note
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This is a research dissertation with project ID: 391121
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| Abstract
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This study aimed to determine the prevalence of NAFLD and its related risk factors and their predictive value among the general population of Isfahan city located in the central part of Iran. In this cross-sectional study the prevalence of non alcoholic fatty liver disease (NAFLD) among general adult population aged 30-60 years was determined using ultrasonography. Anthropometrics and biochemical variables of studied population was measured and compared in groups with and without NAFLD. The predictive value of age, BMI, metabolic risk factors (lipids, FBS) and liver enzymes for occurrence of NAFLD was investigated. Overall 483 subjects ( 291 female and 192 males) with mean age of 45.53+- 8.92 were studied. NAFLD was diagnosed in 190 (39.3 percent) of participants. Frequency of different grades of NAFLD was 46(9.5 percent), 102(21.1 percent), 35(7.2 percent), 7(1.4 percent) for focal fatty infiltration (FFI), grade I, II and III respectively. There was not significant differences between female and male participants regarding the prevalence of different type of NAFLD, FFI and normal groups(P=0.238).Ordinal regression was determined that all of the studied variables have significant predictive value for NAFLD (P<0.001, r =0.615). Spearman correlation indicated that there was a significant relationship between NAFLD and BMI(r=0,37 ,P <0.001 ),age(r=0.15 ,P=0.001),FBS(r=0.20,P<0.001 ), cholesterol(r= 0.19 ,P<0.001 ),triglyceride(r=0.20 ,P<0.001),LDL-C(r=0.16 ,P<0.001 ),SGOT(r=0.17 ,P< 0.001 ) and SGPT(r=0.31,P<0.001). Our findings showed a higher rate of NAFLD among Isfahani adult general population, but considering the high proportion of NAFLD cases was the milder form of the disease (grade I and FFI) and the association of anthropometrics and metabolic variables with occurrence of NAFLD, it seems that interventional studies which target related risk factors could reduce the occurrence of severe form of NAFLD and its related complications.
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| Descriptor
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1. Non-alcoholic Fatty Liver Disease.- Descriptors: Non-alcoholic Fatty Liver Disease
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Liver Disease
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Ultrasonography
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Body Mass Index
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| Added Entry
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Adibi, Atoosa, Supervisor
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Adibi, Peyman, Supervisor
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