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" Reduction of peritoneal adhesion bands by Mycophenolate Mofetil (CellCept) and Prednisolone in rats "
/پرنیان شریعتی
; Behnam Sanei, Mohsen Mahmoudieh
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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103411
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| Doc. No
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T14976
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WI,900,S531r,2014
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| Main Entry
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Shariati, Parnian
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| Title & Author
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Reduction of peritoneal adhesion bands by Mycophenolate Mofetil (CellCept) and Prednisolone in rats/پرنیان شریعتی
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| College
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Schools, Medicine
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| Date
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, 2014
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| Degree
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General Surgery, Specialty
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14 p.: tab
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This is a research dissertation with project ID: 391268
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| Abstract
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The purpose of this study was to assess the efficacy of Prednisolone and CellCept in decreasing postoperative adhesion band formation in rats. Methods: Sixty male rats were randomly divided into three equal groups. A standard midline incision was made on the abdomen of each rats, then 2 ml of 10 percent sterile solution Talc was injected into intra peritoneal cavity in order to induce adhesion. Group 1 served as control group, while group 2 received oral CellCept (15mg/kg/d) and group 3 recieved oral Prednisolone (15mg/kg/d) for 4 weeks. The formation of adhesion bands in control group was significantly higher than the Prednisolon and CellCept group (P <0.001). The amount of adhesion bands in the second group was similar to the third one. Orally administered CellCept is as effective as oral Prednisolone in declining chance of intra peritoneal adhesion band formation, although it causes fewer complications such as infection in rats.
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| Descriptor
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1. Abdomen- surgery.- Discriptors: Abdomen- surgery
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Mycophenolic Acid
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Adhesives
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Prednisolone
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Rats
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| Added Entry
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Sanei, Behnam, Supervisor
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Mahmoudieh, Mohsen, Supervisor
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| Translated Title Supplied by Cataloguer
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مقایسه اثر پردنیزولون و سل سپت در جلوگیری از ایجاد باندهای چسبنده به دنبال لاپاراتومی جراحی های شکم در رت
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