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" Comparison study on the effect of treatment decision bases on renal biopsy and clinical symptoms in the outcome of patients with recurrent lupus nephritis "
/شکرالله حسنی
; Hadi Karimzadeh, Zahra Sayed bonakdar
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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103415
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| Doc. No
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T14989
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| Call number
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WJ,353,H344c,2014
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| Main Entry
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Hasani, Shokrollah
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| Title & Author
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Comparison study on the effect of treatment decision bases on renal biopsy and clinical symptoms in the outcome of patients with recurrent lupus nephritis/شکرالله حسنی
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| College
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Schools, Medical
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| Date
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, 2014
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| Degree
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Rhomatology, Sub Speciality
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| Page No
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16 p.: diag, tab
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| Note
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This is a research dissertation with project ID: 393217
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| Abstract
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Renal involvement in systemic lupus erythmatosus is one of the most serious complications. Relapse occur frequently in patients with lupus nephritis. Several studies reported that renal biopsy is the gold standard for assessing renal activity and hence guiding the treatment The aim of this study was to compare the effects of treatment decisions based on renal biopsy and clinical symptoms on the outcome of patients with recurrent lupus nephritis. Methods: This study is a descriptive study which was conducted in 2012-13 in the Alzahra hospital. The population studies included patients with lupus nephritis who had referred to the rheumatology clinic of this center due to nephritis relapse treatment. All lupus nephritis patients were diagnosed with renal biopsy and had gone into remission by treatment but due to the discontinuation of treatment and other causes, have relapsed. the patients were divided randomly into two groups of 26, the first group treated without re-kidney biopsy and based on clinical and laboratory symptoms and second group were re-biopsied through considering the ethical points. Then their relationship with laboratory findings (BUN, Cr, ANA, ds-DNA, C3, C4, CH50, U/A, cast, proteinuria and treatment and recurrence outcome were compared between the two groups. It should be noted that in this study data study were entered into the computer and analyzed by SPSS soft ware. Results: The mean of SLEDAI-2K index before initial treatment, after the first round of treatment and after the second round of treatment in single biopsy groups and twice biopsy is not significantly different (p = 0.27). Conclusions: The overall conclusion that can be driven from this study is that treatment decisions based on re-biopsy of the kidney or clinical and laboratory findings in patients who relapsed after initial treatment had no significant effect on the recovery of patients and based on the results of this study the outcome was similar in the two groups and since re- biopsy damage the tissue of kidney thus is hardly accepted by patient and in addition to the expenses sometimes consumes the time and cause the resumption of therapy, adoption of a treatment plan in patients with lupus nephritis is recommended based on clinical and laboratory finding and the discretion of the physician and if possible, kidney re- biopsy should be avoide.
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| Descriptor
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1. Lupus Nephritis.- Descriptors: Lupus Nephritis
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Lupus Erythematosus, Systemic
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Kidney Failure, Chronic
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| Added Entry
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Karimzadeh, Hadi, Supervisor
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Sayed Bonakdar, Zahra, Supervisor
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| Translated Title Supplied by Cataloguer
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بررسی تاثیر بیوپسی کلیه در تصمیم گیری درمانی و Outcome بیماران نفریت لوپوسی با عود بیماری و مقایسه آن با تصمیم گیری صرفا براساس علایم بالینی و آزمایشگاهی
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