| |
| center
|
:
|
Isfahan University of Medical Sciences
|
| Document Type
|
:
|
Latin Dissertation
|
| Language of Document
|
:
|
English
|
| Record Number
|
:
|
103420
|
| Doc. No
|
:
|
T15033
|
| Call number
|
:
|
WR,430,R162e,2014
|
| Main Entry
|
:
|
Rakhshanpour, Mehrdad
|
| Title & Author
|
:
|
The efficacy of 5 percent dapsone gel plus oral isotretinoin versus oral isotretinoin alone in acne vulgaris: A randomized double- blind study/مهرداد رخشانپور
|
| College
|
:
|
Schools, Medical
|
| Date
|
:
|
, 2014
|
| Degree
|
:
|
Dermatology, Speciality
|
| Page No
|
:
|
5 p.: tab
|
| Note
|
:
|
This is a dissertation research with project ID: 392090
|
| Abstract
|
:
|
Acne vulgaris, a common human skin condition, is an inflammatory disease characterized by comedones, papules, nodules and possibly scarring. This study aimed to evaluate the efficacy of a combination of 5 dapsone gel plus oral isotretinoin in the treatment of acne vulgaris. Materials and Methods: A randomized, placebo-controlled, study was carried out on patients with moderate to severe acne. The patients were randomly divided in two groups: (dapsone gel and vehicle gel). All Patients were administered oral isotretinoin 20 mg daily and topical gel twice a day for 8 weeks. The Global Acne Assessment Score (GAAS), the number lesions and side-effects were documented at base line and weeks 4, 8 and 12. Results: A total of 58 patients (age range: 18-25 years) were included in our study. The number of lesions was significantly lower in the dapsone-treated group at all follow-up visits (P < 0.001). The mean GAAS score in the dapsone-treated group and in the Placebo-treated group decreased, but there was no statistical difference in two groups (P < 0.001). The side-effects on the dapsone-treated group were a mild burning sensation in 7 patients (24.13 percent), mild erythema of the skin and mild dryness in 4 (13.79 percent) and 3 (10.34 percent) cases respectively (P < 0.001). In our study, adverse effects were common but they were minor and tolerable. No clinically significant changes in laboratory parameters were observed (P < 0.001). Conclusions: Dapsone gel was an effective medication for patients who received isotretinoin for acne vulgaris treatment resulting in a significant reduction of the number of lesions.
|
| Descriptor
|
:
|
1. Acne Vulgaris .- Descriptors: Acne Vulgaris
|
|
|
:
|
Dapsone
|
|
|
:
|
Isotretinoin
|
| Added Entry
|
:
|
Faghihi, Gita, Supervisor
|
| | | | | |
| | |  |
http://elib.mui.ac.ir/site/catalogue/103420
| | | |
| | | |
|