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" Effect of vitamin D therapy on endothelial function in ischemic heart disease female patients with vitamin D deficiency or insufficiency. A Primary Report "


center : Isfahan University of Medical Sciences
Document Type : Latin Dissertation
Language of Document : English
Record Number : 103421
Doc. No : T15032
Call number : ‭WG,500,M726e,2014‬
Main Entry : Mokhtari, Meisam
Title & Author : Effect of vitamin D therapy on endothelial function in ischemic heart disease female patients with vitamin D deficiency or insufficiency. A Primary Report/میثم مختاری
College : Schools, Medical
Date : , 2014
Degree : Cardiology, Speciality
Page No : 16 p.: tab
Note : This thesis is a research project with project ID: 392128
Abstract : Vitamin D deficiency is associated with vascular endothelial dysfunction. We evaluated endothelial function in ischemic heart disease (IHD) patients with vitamin D deficiency or insufficiency before and after vitamin D therapy. Methods: An uncontrolled before-after study was conducted in Isfahan, Iran on consecutive sample of female IHD patients who had undergone percutaneous coronary intervention in the preceding six months and/or referred with chronic stable angina. Forty patients with vitamin D deficiency or insufficiency (serum 25-hydroxyvitamin D <20 or 20-30 ng/ml, respectively) were included and received two intramuscular injections of 300,000 IU cholecalciferol with one month interval. Endothelial function, assessed by measuring flow-mediated dilatation (FMD), and serum 25-hydroxy vitamin D level were measured at baseline and one month after the second dose of cholecalciferol. Results: Thirty patients completed the study, age = 59.4 +- 8.7 years; serum 25-hydroxyvitamin D= 19.0 +- 6.5ng/ml. After treatment, serum 25-hydroxy vitamin D was reached to > 30 ng/mL in all patients. Brachial artery diameter (mm) after ischemia increased significantly, statistically but not clinically (4.55 +- 0.37 to 4.67 +- 0.38, P < 0.001). Also, FMD( percent) was increased from 1.96 +- 1.65 to 4.65 +- 1.27 (P < 0.001). The amount of change in FMD was not significantly correlated with serum 25-hydroxy vitamin D (r = 0.038, P = 0.858). Conclusion: Endothelial function was improved after vitamin D therapy in IHD patients with low serum vitamin D. Controlled studies with larger sample size are required to confirm if vitamin D therapy has effects on endothelial function.
Descriptor : 1. Vascular Diseases .- Descriptors: Vascular Diseases
: Endothelium
: Coronary Artery Disease
: Vitamin D Deficiency
Added Entry : Hashemi, Mohammad, Supervisor
: Sadeghi, Masoumeh, Supervisor
Translated Title Supplied by Cataloguer : بررسی اثر مکمل ویتامین D بر عملکرد اندوتلیال در بیماران مونث مبتلا به بیماری ایسکمیک قلبی و کمبود ویتامین D
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