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" Effect of vitamin D therapy on endothelial function in ischemic heart disease female patients with vitamin D deficiency or insufficiency. A Primary Report "
/میثم مختاری
; Mohammad Hashemi, Masoumeh Sadeghi
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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103421
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| Doc. No
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T15032
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| Call number
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WG,500,M726e,2014
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| Main Entry
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Mokhtari, Meisam
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| Title & Author
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Effect of vitamin D therapy on endothelial function in ischemic heart disease female patients with vitamin D deficiency or insufficiency. A Primary Report/میثم مختاری
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| College
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Schools, Medical
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| Date
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, 2014
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| Degree
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Cardiology, Speciality
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16 p.: tab
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| Note
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This thesis is a research project with project ID: 392128
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| Abstract
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Vitamin D deficiency is associated with vascular endothelial dysfunction. We evaluated endothelial function in ischemic heart disease (IHD) patients with vitamin D deficiency or insufficiency before and after vitamin D therapy. Methods: An uncontrolled before-after study was conducted in Isfahan, Iran on consecutive sample of female IHD patients who had undergone percutaneous coronary intervention in the preceding six months and/or referred with chronic stable angina. Forty patients with vitamin D deficiency or insufficiency (serum 25-hydroxyvitamin D <20 or 20-30 ng/ml, respectively) were included and received two intramuscular injections of 300,000 IU cholecalciferol with one month interval. Endothelial function, assessed by measuring flow-mediated dilatation (FMD), and serum 25-hydroxy vitamin D level were measured at baseline and one month after the second dose of cholecalciferol. Results: Thirty patients completed the study, age = 59.4 +- 8.7 years; serum 25-hydroxyvitamin D= 19.0 +- 6.5ng/ml. After treatment, serum 25-hydroxy vitamin D was reached to > 30 ng/mL in all patients. Brachial artery diameter (mm) after ischemia increased significantly, statistically but not clinically (4.55 +- 0.37 to 4.67 +- 0.38, P < 0.001). Also, FMD( percent) was increased from 1.96 +- 1.65 to 4.65 +- 1.27 (P < 0.001). The amount of change in FMD was not significantly correlated with serum 25-hydroxy vitamin D (r = 0.038, P = 0.858). Conclusion: Endothelial function was improved after vitamin D therapy in IHD patients with low serum vitamin D. Controlled studies with larger sample size are required to confirm if vitamin D therapy has effects on endothelial function.
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| Descriptor
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1. Vascular Diseases .- Descriptors: Vascular Diseases
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Endothelium
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Coronary Artery Disease
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Vitamin D Deficiency
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| Added Entry
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Hashemi, Mohammad, Supervisor
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Sadeghi, Masoumeh, Supervisor
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| Translated Title Supplied by Cataloguer
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بررسی اثر مکمل ویتامین D بر عملکرد اندوتلیال در بیماران مونث مبتلا به بیماری ایسکمیک قلبی و کمبود ویتامین D
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