|
" The effect of neutral oligosaccharides on reducing the incidence of necrotizing enterocolotis in preterm infants: A randomized clinical trial "
/مریم حسینزاده
; Amir Mohammad Armanian, Alireza Sadeghnia
| center
|
:
|
Isfahan University of Medical Sciences
|
| Document Type
|
:
|
Latin Dissertation
|
| Language of Document
|
:
|
English
|
| Record Number
|
:
|
103453
|
| Doc. No
|
:
|
T15063
|
| Call number
|
:
|
WI,420,H825e,2014
|
| Main Entry
|
:
|
Hoseinzadeh, Maryam
|
| Title & Author
|
:
|
The effect of neutral oligosaccharides on reducing the incidence of necrotizing enterocolotis in preterm infants: A randomized clinical trial/مریم حسینزاده
|
| College
|
:
|
Schools, Medical
|
| Date
|
:
|
, 2014
|
| Degree
|
:
|
Pediatric, Speciality
|
| Page No
|
:
|
23 p.: tab.
|
| Note
|
:
|
This thesis is a research project with project ID: 392237
|
| Abstract
|
:
|
Background and Objective: Necrotizing enterocolitis (NEC) is one of the most destructive diseases associated with conditions of neonatal prematurity. Supplementation with enteral prebiotics may reduce the incidence of NEC, especially in infants who fed exclusively with breast-milk. Therefore we compared the efficacy and safety of enteral supplementation of a prebiotic mixture (SCGOS/LCFOS) versus no intervention on incidence of NEC in preterm infants. Methods: In a single-centre randomized control trial 75 preterm infants (birth weight <= 1500 gr, gestational age <= 34 wk. and were not fed with formula) on 30 ml/kg/day volume of breast milk were randomly allocated to receive enteral supplementation with a prebiotic mixture (SCGOS/LCFOS; 9:1), or not receive any prebiotic. The incidence of suspected NEC, feeding intolerance, time to full enteral feeds, and duration of hospitalization were investigated. Results: Differences in demographic characteristics were not statistically important. SCGOS/LCFOS mixture significantly reduced the incidence of suspected NEC, (1 (4.0 percent) versus 11 (22.0 percent); HR: 0.49 (95 CI: 0.29-0.84); P: 0.009), and time to full enteral feeds (11 (7-21) versus 14 (8-36) days; P: 0.02). Duration of hospitalization was also meaningfully shorter in the prebiotic group (16 (9-45) versus 25 (11-80); P: 0.004). Prebiotic oligosaccharides were well tolerated by very low birth weight (VLBW) infants. Conclusion: Enteral supplementation with prebiotic significantly reduced the incidence of NEC in VLBW infants who were fed exclusively breast milk. This finding suggests that it might have been the complete removal of formula which caused a synergistic effect between non-human neutral oligosaccharides (prebiotic) and human oligosaccharides.
|
| Descriptor
|
:
|
1. Enterocolitis, Necrotizing.- Descriptors: Enterocolitis, Necrotizing
|
|
|
:
|
Oligosaccharides
|
|
|
:
|
Infant, Newborn
|
|
|
:
|
Breast Feeding
|
|
|
:
|
Infant, Premature
|
| Added Entry
|
:
|
Armanian, Amir Mohammad, Supervisor
|
|
|
:
|
Sadegnia, Alireza, Supervisor
|
| Translated Title Supplied by Cataloguer
|
:
|
بررسی اثر الیگوساکاریدهای خنثی در کاهش بروز NEC در نوزادان VLBW در بیمارستانهای الزهرا و شهید بهشتی اصفهان
|
| |