|
" Evaluation of bone density, serum total and ionized calcium, alkaline phosphatase and 25-hydroxy vitamine D in papollary thyroid carcinoma, and their relationship with TSH suppression by levothyroxine "
/ماشاالله طباطباییزاده
; Ali Kachuie, Bijan Iraj
| center
|
:
|
Isfahan University of Medical Sciences
|
| Document Type
|
:
|
Latin Dissertation
|
| Language of Document
|
:
|
English
|
| Record Number
|
:
|
103454
|
| Doc. No
|
:
|
T15062
|
| Call number
|
:
|
WK,270,T112e,2014
|
| Main Entry
|
:
|
tabatabaeizadeh, Mashaallah
|
| Title & Author
|
:
|
Evaluation of bone density, serum total and ionized calcium, alkaline phosphatase and 25-hydroxy vitamine D in papollary thyroid carcinoma, and their relationship with TSH suppression by levothyroxine/ماشاالله طباطباییزاده
|
| College
|
:
|
Schools, Medical
|
| Date
|
:
|
, 2014
|
| Degree
|
:
|
Endocrinology, SubSpeciality
|
| Page No
|
:
|
24 p.: tab.
|
| Note
|
:
|
This thesis is a research project with project ID: 392303
|
| Abstract
|
:
|
Background: This study aimed to evaluate the situation of BMD, Z score, T score, Serum level of corrected and ionized calcium, alkaline phosphatase and 25-hydroxy vitamin D in PTC patients and correlation of these variants with TSH suppression level by levothyroxine. Materials and methods: Among the patients referred to Esfahan`s endocrinology research center, 34 PTC patients (age 20-50 years) with the history of thyroidectomy, and conceived radioactive Iodine and suppressive dose of levothyroxine were evaluated in this case - control study and 38 healthy persons were participated as the control group (matched by age and sex, BMI). Bone density evaluated with DEXA method in four area; lumber spine, femoral Neck, Trochanter and distal of forearm. Reference laboratory was assessed TSH, Corrected and ionized calcium, ALP, and 25OH vitamin D level using fasting plasma, and evaluated correlation of TSH level with variants by multivariate variance analysis. Results: There was no significant difference in bone density and laboratory data (unless TSH) between the both groups. In PTC group there was no significant correlation between TSH and difference values of BMD, Z score or T score, also corrected calcium (P value: 0.12), Ionized calcium (P: 0.54), Alp (P: 0.22) and 25 OH vitamin D (P: 0.38). No significant correlation was in TSH Subgroups with BMD. TSH suppression level has not relation with elevated prevalence of low BMD, hypocalcaemia and vitamin D deficiency. Difference in odds ratio was not significant for osteopenia and osteoporosis between TSH Subgroups (TSH<0.02, >0.02 and <0.1, and >0.1mu/L). Conclusion: Suppressive therapy with levothyroxine cannot decrease BMD, Z score and T score, in PTC patients. Key words: TSH, Alp, T score, Z score, BMD, PTC, DEXA, ionized calcium, corrected calcium,25 OH vitamin D.
|
| Descriptor
|
:
|
1. Thyroid cancer, papillary.- Descriptors: Thyroid cancer, papillary
|
|
|
:
|
Bone Density
|
|
|
:
|
Serum
|
|
|
:
|
Calcium
|
|
|
:
|
Alkaline Phosphatase
|
|
|
:
|
Thyroxine
|
|
|
:
|
Thyroid Neoplasms
|
| Added Entry
|
:
|
Kachuie, Ali, Supervisor
|
|
|
:
|
Iraj, Bijan, Supervisor
|
| Translated Title Supplied by Cataloguer
|
:
|
بررسی وضعیت تراکم استخوان -کلسیم کلی و یونیزه و الکالن فسفاتاز سرم در بیماران مبتلا به سرطان پاپیلاری تیروئید و ارتباط آنها با میزان مهار TSH توسط لووتیروکسین
|
| |