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" Screening and evaluation of chronic and occult Hepatitis B in chemo -- radiotherapy patients with cancer "
/محمد غلامنژاد
; Mohsen Meidani, Mojtaba Rostami
; Simin Hemmati, Farzaneh Ashrafi
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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103458
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| Doc. No
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T14981
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| Call number
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WC,536,G427s,2014
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| Main Entry
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Gholamnezhad, Mohammad
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| Title & Author
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Screening and evaluation of chronic and occult Hepatitis B in chemo -- radiotherapy patients with cancer/محمد غلامنژاد
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| College
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Schools, Medical
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| Date
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, 2014
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| Degree
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Infection Disease, Speciality
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15 p.: tab
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| Note
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This is a research dissertation with project ID: 392049
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| Abstract
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Hepatitis B virus infection (HBV) and its complications is one of the most serious problems of the health system in many parts of the world. Reactivation of hepatitis B due to chemo -- radiotherapy is a serious cause of morbidity and mortality in patients with cancer. In the present study, we will assess chronic and occult HBV and isolated anti-Hepatitis B core antigen whose screening and evaluation is not routine in different populations. Materials and Methods: This descriptive -- analytical study was conducted on 213 patients undergoing chemotherapy -- radiotherapy referred to the hematology -- oncology clinics of Isfahan, Iran in 2012. In order to determine the serum levels of HbSAg, HBCAb, AST, ALT and ALK.P, venous blood samples were obtained. If the HBCAb sample was positive, another sample of the serum was sent to the laboratory to perform polymerase chain reaction and to determine viral load. Results: The mean age of the patients was 47.7 +- 9 years, with an age range of 27 - 73 years; 98 (46 percent) and 115 (54 percent) cases were male and female, respectively, with mean ages of 51.9 +- 8.3 and 44.1 +- 8.1 years, and there was no significant difference (P < 0.001). The mean level of liver enzymes including AST, ALT and ALK.P were 34.2 +- 36.02, 38.9 +- 47.1 and 252.1 +- 234.7, respectively. Two cases were HbSAg positive (0.9 percent) and six cases were HBCAb positive (2.8percent ) and HbSAg negative. Three cases had a high viral load at the rate of starting treatment among positive anti-HBC patients. Conclusion: Screening and evaluating the status of patients for Hepatitis B before chemo -- radiotherapy is necessary. Because occult hepatitis is investigated less commonly in routine studies, it seems that screening and evaluating its prevalence is useful in the management of patients.
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| Descriptor
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1. Hepatitis B.- Descriptors: Hepatitis B
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Chemoradiotherapy
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Hepatitis B Virus
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Neoplasms
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| Added Entry
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Meidani, Mohsen, Supervisor
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Rostami, Mojtaba, Supervisor
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Hemmati, Simin, Advisor
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Ashrafi, Farzaneh, Advisor
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| Translated Title Supplied by Cataloguer
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اسکرین هپاتیت مزمن B و نهفته در بیماران کاندید کمورادیوتراپی
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